Publications by authors named "Samuel B Governor"
Background: Survival differences between left-sided colon cancer (LSCC) and right-sided colon cancer (RSCC) has been previously reported with mixed results, with various study periods not accounting for other causes of mortality.
Purpose: We sought to assess the trends in colon cancer cause- specific survival (CSS) and overall survival (OS) based on sidedness.
Method: Fine-Gray competing risk and Cox models were used to analyze Surveillance, Epidemiology, and End Results (SEER) population-based cohort from 1975 to 2019.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the coronavirus 19 (COVID-19) pandemic have had a lasting impact on the care of cancer patients. The impact on patients with gastrointestinal (GI) malignancies remains incompletely understood. We aimed to assess the impact of COVID-19 on mortality, length of stay (LOS), and cost of care among patients with GI malignancies, and identify differences in outcomes based on primary tumor site.
View Article and Find Full Text PDFBackground: 25% of all breast cancer patients have HER-2 overexpression. Breast Cancer patients with HER-2 overexpression are typically treated with HER-2 inhibitors such as Trastuzumab. Trastuzumab is known to cause a decrease in left ventricular ejection fraction.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal cancer (CRC) sidedness, with left-sided CRC linked to better survival rates than right-sided CRC (RsCC), is influenced by factors like obesity, race, age, and sex.
- A study analyzed data from nearly 25,000 CRC patients, revealing 13.6% were overweight and 49.9% were obese, predominantly non-Hispanic Whites, while overweight and obese individuals had a higher likelihood of developing RsCC.
- The findings highlight that obesity raises the risk of RsCC, particularly emphasizing significant racial disparities in CRC outcomes among obese patients.
Article Synopsis
- Gastrointestinal extrapulmonary small cell carcinoma (GI EPSCCa) is a rare and aggressive type of cancer, and factors influencing survival, like the site of the primary tumor, are still being studied.
- Data from the SEER program (2000-2018) showed that most patients had tumors in the colorectum, esophagus, and pancreas, with notable racial differences in tumor locations but no differences in overall survival among races.
- The study found that different tumor sites affect patient prognosis, with some treatments like surgery and therapies after 2006 leading to better outcomes, though the overall survival rates for GI EPSCCa patients remain poor, highlighting the need for further research.