Publications by authors named "Samira Nasirizadeh"
Wound healing is a complex process that orchestrates the coordinated action of various cells, cytokines and growth factors. Nanotechnology offers exciting new possibilities for enhancing the healing process by providing novel materials and approaches to deliver bioactive molecules to the wound site. This article elucidates recent advancements in utilizing nanoparticles, nanofibres and nanosheets for wound healing.
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- The study focused on developing and characterizing a new formulation of undecylenoyl phenylalanine (Sepiwhite) loaded into nanostructured lipid carriers (NLCs) aimed at reducing melanin production in the skin.
- An optimized SEPI-NLC formulation showed promising results with a small particle size of 180.1 nm, high entrapment efficiency of 90.81%, and a stable shelf life of 9 months at room temperature.
- The findings indicated that SEPI-NLCs had superior skin permeation and anti-tyrosinase activity compared to traditional formulations, indicating their potential effectiveness for treating hyperpigmentation.
Background: Hyperpigmentation is darkened patches or spots on the skin occurred by increased melanin. Undecylenoyl phenylalanine (Sepiwhite®), as a commercial lipophilic derivative of phenylalanine, is a powerful new brightener that can be used in the treatment of skin pigmentation disorders.
Aims: Solid lipid nanoparticles (SLNs) increase the efficiency of hydrophobic drugs.