Publications by authors named "Samarkand A Estee"
Article Synopsis
- The study presents a high-throughput (HT) method for creating natural product libraries using LC-MS-UV-ELSD to identify new bioactive compounds and molecular structures.
- An extract from the marine sponge Cacospongia mycofijiensis was tested, revealing twelve known compounds with bioactivity against the parasite T. brucei and selectivity for lymphoma tumor cells.
- Four new compounds were discovered, showcasing valuable derivatives, and the methodology's advantages in avoiding false positives in bioactivity screening are highlighted, emphasizing its potential in accelerating drug discovery.
In order to compare the utility of standard solvent partitioning (SSP) versus accelerated solvent extraction (ASE), a series of experiments were performed and evaluated. Overall yields, solvent consumption, processing time, and chemical stability of the fractions obtained by both methods were compared. Five marine sponges were selected for processing and analysis containing 12 structurally distinct, bioactive natural products.
View Article and Find Full Text PDF