Sun-Safety Knowledge, Attitudes and Behaviour in Western Saudi Arabia: Implications for Psycho-Oncology Prevention Services.

Background: Melanoma, a highly aggressive skin cancer, is strongly linked to ultraviolet (UV) exposure. Despite high UV levels in Saudi Arabia, public awareness and adherence to melanoma preventive behaviours remain underexplored. This study assessed knowledge (factual accuracy), attitudes, and sun-protective practices among adults in the western region of Saudi Arabia, investigating demographic and gender-specific differences.

Identification of adipose-proximal biomarkers in breast cancer using weighted gene co-expression network analysis.

Breast cancer is a widely studied cancer that involves multiple complex molecular mechanisms in its development and progression. To gain a deeper understanding of the molecular mechanisms of breast cancer and to search for potential therapeutic targets and prognostic markers, we performed an in-depth analysis of breast cancer gene expression data using weighted co-expression network analysis. First, we downloaded breast cancer-related gene expression data from public databases and performed weighted co-expression network analysis.

Mutational spectrum and profile of breast and ovarian cancer patients in Saudi Arabia's western region: single center experience.

Background: The incidence of breast cancer (BC) and ovarian cancer (OC) has increased in Saudi Arabia. The western region of Saudi Arabia presents a unique population with distinct genetic backgrounds, making it vital to investigate the prevalence of BC/OC-associated gene mutations in this area. This study aimed to determine the prevalence and mutational profiles of BC and/or OC predisposing genes in the western region of Saudi Arabia, and to characterize the associated phenotypes in individuals carrying these mutations.

Descriptive epidemiology of female breast cancer around the world: incidence, mortality, and sociodemographic risks and disparities.

This review provides descriptive evidence for the potential sociodemographic risk factors of race/ethnicity, younger age, and socioeconomic status, as well as evidence for the immigrant effect in women with breast cancer (BC) across world regions and countries. Using MEDLINE and the Web of Science on epidemiology, incidence/mortality rates, and social determinants, we searched a registry-based dataset and the reference lists of prior reviews of BC women (code C50) from the GLOBOCAN 2022 database and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program 2024. Globally, 1,959,256 new cases (26.

Cerebral dural arteriovenous fistulas in patients with PTEN-related hamartoma tumor syndrome.

Central nervous system (CNS) dural arteriovenous fistulas (DAVF) have been reported in PTEN-related hamartoma tumor syndrome (PHTS). However, PHTS-associated DAVF remain an underexplored field of the PHTS clinical landscape. Here, we studied cases with a PTEN pathogenic variant identified between 2007 and 2020 in our laboratory (n = 58), and for whom brain imaging was available.

Checkpoint Kinase 2 (CHEK2) Gene Mutation in a Patient With Breast and Prostate Cancer: A Unique Presentation of a Rare Disease.

Breast cancer is one of the rarest malignancies in males, with a low incidence rate compared to all breast cancers. Gene mutation plays a significant role in the pathologic process of cancer. Mutations in breast cancer gene 1 () and breast cancer gene 2 () have been associated with male breast cancer (MBC), as well as prostate cancer (PCa).

Comparison of Knowledge of Lactose Intolerance and Cow's Milk Allergy Among the Medical Students at Two Universities in Saudi Arabia.

Lactose intolerance is a condition causing an inability to absorb and digest lactose leading to gastrointestinal symptoms such as abdominal pain, diarrhea, and flatulence. Because of the similarities between lactose intolerance and cow's milk allergy, it is becoming necessary to increase physicians' understanding of these two diseases. Consequently, we aimed to determine the level of knowledge of lactose intolerance and cow's milk allergy among medical students.

Prospective Functions of miRNA Variants May Predict Breast Cancer Among Saudi Females.

Background Growing knowledge supports the importance of microRNAs (miRNAs) in modulating the initiation and development of breast cancer (BC) and underlying mechanisms. BC is a significant public health in females worldwide, where it remains the leading cause of death among Saudi females. Here, we evaluate the susceptibility of the miRNA genetic variants to the risk of BC in Saudi females.

Knowledge of Cancer Genetics and the Importance of Genetic Testing: A Public Health Study.

Background Cancer represents a global concern as the second-leading cause of mortality worldwide. It is defined as a genetic disease that develops as a result of several genetic abnormalities and changes to specific genes. Thus, early preventive measures and clinical interventions can be implemented with impressive results using genetic testing and screening for hereditary susceptibility.

Corrigendum to "Anti- immunoglobulin yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in load" [Heliyon 9(3) (February 21, 2023) e13876]>.

[This corrects the article DOI: 10.1016/j.heliyon.

Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma.

Background: The  and immunoproteasomegenes are essential in cell processes, such as decisions on cell survival or death, the cell cycle, and cellular differentiation. Because recent evidence has demonstrated an immunological role for proteasomes in various malignancies, including urothelial bladder carcinoma (UBC), we evaluated single nucleotide polymorphisms (SNPs) in  and . We determined any associations between these SNPs and susceptibility to UBC in the Saudi community.

Anti- Immunoglobulin Yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in load.

Graft versus host disease (GVHD) remains the major cause of morbidity and mortality after allogeneic stem cell transplantation, especially for intestinal GVHD, as steroid resistant GVHD results in high mortality. For this reason, new treatments of GVHD are needed. One approach is the reduction of pathogenic bacteria using anti- Immunoglobulin Yolk (IgY).

Variations in and Genes Involved in Antigen Processing and Presentation Increase the Risk of Vitiligo in the Saudi Community.

Background: The antigen processing 1 () and proteasome 20S subunit beta 9 () genes are associated with strong susceptibility to many autoimmune diseases. Here, we explored whether genetic variants, individually or combined, affected susceptibility to the complex, autoimmune-based skin disorder vitiligo.

Methods: Samples of genomic DNA from buccal cells of 172 patients with vitiligo and 129 healthy controls were analyzed using genotyping assays for the rs1135216 (A>G) and rs17587 (A>G) single nucleotide polymorphisms (SNPs).

Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of the , and Genes Among Nonsmokers in the Saudi Community.

Purpose: Colorectal carcinoma (CRC) represents a considerable public health burden in Saudi Arabia. Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. We explored whether allelic variants of the (rs4646903 and rs1048943), and (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC.