Publications by authors named "Samantha K Korver"
Article Synopsis
- This study investigates the adverse effects of fluoropyrimidine-based chemotherapy and aims to identify genetic and non-genetic predictors of these side effects.
- Researchers analyzed genomic DNA for 25 single nucleotide polymorphisms (SNPs) and collected demographic and treatment data from 155 Australian participants.
- Results showed associations between multiple genetic and non-genetic predictors with various adverse effects, particularly highlighting diarrhea as the most common severe side effect, and suggest further research is needed to understand these predictors' clinical significance.
Purpose: Severe gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients' quality of life. There are no adequate predictors for 5-FU-induced severe GI toxicity risk.
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