Publications by authors named "Samantha D Foster"
The development of gene editing technologies, especially the CRISPR-Cas9 system, has been pivotal for understanding the functional role of proteins. Rapid and efficient genotyping methods are necessary to screen for generated mutations and streamline the isolation of homozygotes. CRISPR-Cas9 system targeting a single site in the gene typically results in small indels.
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- * The study successfully utilized the CRISPR-Cas9 system to target and induce specific mutations in the ndr2 gene in zebrafish embryos, leading to the expected cyclopic phenotypes.
- * Analysis revealed that most induced mutations resulted in small changes that disrupted normal gene function, enhancing the understanding of ndr2's role and demonstrating the effectiveness of CRISPR technology for targeted genetic studies.