Publications by authors named "Sakae Ihara"
Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy.
Transl Psychiatry
August 2025
Cognitive behavioral therapy (CBT) and pharmacotherapy are primary treatments for major depressive disorder (MDD). However, their differential effects on the neural networks associated with rumination, or repetitive negative thinking, remain poorly understood. This study included 135 participants, whose rumination severity was measured using the rumination response scale (RRS) and whose resting brain activity was measured using functional magnetic resonance imaging (fMRI) at baseline and after 16 weeks.
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- This study examines the effectiveness of combining cognitive behavioral therapy (CBT) with medication versus medication alone in improving coping strategies and reducing depressive symptoms in patients with major depression.
- Researchers analyzed changes in stress coping strategies and depression severity over 16 weeks in two groups of patients: one receiving CBT and medication, and the other receiving only medication.
- Results indicated that the CBT group developed better coping skills and experienced a significantly greater decrease in depressive symptoms compared to the pharmacotherapy group, suggesting the benefits of integrating coping strategies in treatment plans.
Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study.
Neuropsychiatr Dis Treat
November 2022
Purpose: Major depression is a heterogeneous disorder. Therefore, careful evaluation and comprehensive assessment are crucial elements for achieving remission. Personality traits influence prognosis and treatment outcomes, but there is not enough evidence on the association between personality traits and sustained remission (SR).
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