Systemic administration of gold nanoparticles attenuates anxiety-related behaviors and enhances spatial learning performance in rats.

Background: Due to the unique characteristics of gold nanoparticles, including low toxicity, tissue compatibility, high surface-to-volume ratio, excellent stability, lack of immunogenicity, and the ability to cross the blood-brain barrier, gold nanoparticles can affect brain cells and impact neuronal functions. This study aimed to investigate the effect of gold nanoparticles (AuNPs) on rats' anxiety, memory, and learning ability.

Method: This study was conducted on 35 male Wistar rats that were obtained from the Animal Center of Baqiyatallah University.