Publications by authors named "Sahand Emamian"
Article Synopsis
- The study focuses on how IgM antibodies, which are produced in patients with hemophilia A, interact with factor VIII (FVIII) and potentially influence the development of harmful IgG inhibitors.
- Researchers identified specific FVIII-targeting IgM antibodies from mice and analyzed their binding capabilities using advanced lab techniques.
- Results indicated that while the IgM antibodies can bind to FVIII, they do not significantly influence the production of IgG inhibitors, suggesting that IgM's role may be limited in this context.
Enzyme reactivity is often enhanced by changes in oxidation state, spin state, and metal-ligand covalency of associated metallocofactors. The development of spectroscopic methods for studying these processes coincidentally with structural rearrangements is essential for elucidating metalloenzyme mechanisms. Herein, we demonstrate the feasibility of collecting X-ray emission spectra of metalloenzyme crystals at a third-generation synchrotron source.
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