Publications by authors named "Sadamitsu Ichijyo"
Article Synopsis
- - The prevalence of Alzheimer's disease (AD) is rising globally, and a new therapy using low-intensity pulsed ultrasound (LIPUS) has shown promise in animal studies for treating AD and vascular dementia.
- - Two trials were conducted: one for safety and a double-blind, placebo-controlled trial examining efficacy; both used LIPUS therapy applied to the entire brain at specific parameters.
- - Results indicated no adverse effects in the small initial trial and a potential reduction in cognitive decline in the LIPUS group compared to placebo, but further research with a larger sample size is needed.
Coronary physiological assessment combining fractional flow reserve and index of microcirculatory resistance in patients undergoing elective percutaneous coronary intervention with grey zone fractional flow reserve.
Catheter Cardiovasc Interv
November 2018
Objectives: The aim of this study is to investigate the association between fractional flow reserve (FFR) values and change in coronary physiological indices after elective percutaneous coronary intervention (PCI).
Background: Decision making for revascularization when FFR is 0.75-0.
Background: The hemodynamics involved in the relationship between absolute coronary blood flow (ABF) volume and myocardial resistance (MR) are complex, and the effect of percutaneous coronary intervention (PCI) on their changes remains unclear. The aim of this study was to investigate the differences in hyperemic ABF and MR before and after elective PCI using a thermodilution method.
Methods And Results: We investigated 28 vessels (right coronary artery, 9; left anterior descending coronary artery, 18; left circumflex coronary artery, 1) from 28 patients with stable angina pectoris undergoing elective PCI.
Background: The relationship between the features of morphologically unstable plaque and physiological lesion severity remains elusive. We aimed to investigate this relationship using optical coherence tomography (OCT)-derived high-risk plaque characteristics and fractional flow reserve (FFR) as the degree of anatomical and physiological stenosis severity.
Methods and results: We investigated 286 de novo intermediate and severe coronary lesions in 248 patients who underwent OCT and FFR examinations.
Background: Fractional flow reserve (FFR) and coronary flow reserve (CFR) are well-validated physiological indices; however, changes in FFR and CFR after percutaneous coronary intervention (PCI) remain elusive. We sought to evaluate these changes and to investigate whether physiological indices predict cardiac event-free survival after PCI.
Methods And Results: Physiological assessment of 220 stenoses from 220 patients was performed before and after PCI.
The influence of elective percutaneous coronary intervention on microvascular resistance: a serial assessment using the index of microcirculatory resistance.
Am J Physiol Heart Circ Physiol
September 2016
This study investigates whether hyperemic microvascular resistance (MR) is influenced by elective percutaneous coronary intervention (PCI) by using the index of microcirculatory resistance (IMR). Seventy-one consecutive patients with stable angina pectoris undergoing elective PCI were prospectively studied. The IMR was measured before and after PCI and at the 10-mo follow-up.
View Article and Find Full Text PDFBackground: Despite evidence demonstrating the benefits of percutaneous coronary intervention guided by fractional flow reserve (FFR), FFR evaluation has not been widely adopted. We sought to compare the diagnostic performances of instantaneous wave-free ratio (iFR) to a novel contrast medium-induced index in FFR prediction, hypothesizing that the latter parameter would offer superior diagnostic agreement with FFR.
Methods & Results: We studied 132 intermediate stenoses in 97 patients prospectively.