Synthesis of benzo[,]quinoline-spiro-succinimides rhodium-catalyzed C-H activation/annulation of 1-naphthylamides with maleimides.

This study unveils the first rhodium-catalyzed synthesis of benzo[,]quinoline-spiro-succinimides C-H activation/annulation of 1-naphthylamides with maleimides, utilizing picolinamide as a directing group. This method boasts a broad substrate scope, excellent yields, and wide range of functional group tolerance. Mechanistic insights and promising photoluminescence are reported, demonstrating an efficient route to valuable all-carbon quaternary spirocyclic compounds.

Palladium(II)/Lewis acid catalyzed oxidative olefination of 2-benzamidopyridine 1-oxide with acrylates: synthesis of isoindolinones.

A palladium(II)/Lewis acid-catalyzed C-H olefination of 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition for the synthesis of isoindolinones has been developed. The use of a heterobimetallic Pd(II)/Cu(II) catalyst enhances the efficiency of the reaction, enabling the synthesis of a potential anti-sedative agent.

Cobalt-Catalyzed Regioselective C8-H Sulfoxamination of 1-Naphthylamine Derivatives with NH-Sulfoximines.

A simple cobalt-catalyzed, picolinamide-directed C8-H sulfoxamination of 1-naphthalamides with NH-sulfoximines has been developed. This cross-dehydrogenative C-H/N-H coupling reaction offers a facile route to N-arylated sulfoximines, exhibiting high yields, a broad substrate scope, and excellent functional group tolerance and scalability.

Palladium-Catalyzed Chelation-Assisted Aldehyde C-H Bond Activation of Quinoline-8-carbaldehydes: Synthesis of Amides from Aldehydes with Anilines and Other Amines.

A palladium-catalyzed chelation-assisted direct aldehyde C-H bond amidation of quinoline-8-carbaldehydes with an amine was developed under mild reaction conditions. A wide range of amides were obtained in good to excellent yields from aldehyde with a variety of aniline derivatives and aliphatic amines. Our methodology was successfully applied to synthesize known DNA intercalating agents and can be easily scaled up to a gram scale.