Dissolution Enhancement of Lycopene Compacts by Liquisolid Technique.

Objectives: Lycopene is a powerful antioxidant with diverse health benefits. However, it belongs to the Biopharmaceutics Classification System II; thus, it depicts poor water solubility and dissolution. Its lipophilic nature hinders the bioavailability of this drug.

Dose Optimization of NMDA for Rat model of Infantile Spasms: Approach Using EEG, Behavior (Seizure) and Histopathology.

Infantile Epileptic Spasms Syndrome (IESS), also referred to as West syndrome, is a severe epileptic disorder that emerges during early childhood. It is marked by characteristic epileptic spasms, developmental stagnation or regression, and a distinctive electroencephalogram (EEG) pattern known as hypsarrhythmia. To better understand the underlying mechanisms of IESS, various genetic and chemically induced animal models have been developed.

Comparison of single-shot neuraxial morphine and erector spinae plane block on quality of recovery after major open gastrointestinal surgeries: A prospective, randomized trial.

Background: It is crucial to assess a patient's quality of recovery after major surgery. This study aims to compare the effect of neuraxial morphine and bilateral erector spinae plane block on quality of recovery in the first 48 postoperative hours in patients undergoing open upper abdominal surgeries.

Methods: This prospective, triple-arm, randomized study was performed to compare the effect of neuraxial morphine (intrathecal morphine, thoracic epidural) and erector spinae plane block on postoperative recovery.

A Precision Gene Engineered B Cell Medicine Producing Sustained Levels of Active Factor IX for Hemophilia B Therapy.

Hemophilia B gene therapy treatments currently have not addressed the need for predictable, durable, active, and redosable factor IX (FIX). Unlike conventional gene therapy, engineered B Cell Medicines (BCMs) are durable, redosable, and titratable, and thus have the potential to address significant unmet needs in the Hemophilia B treatment paradigm. BE-101 is an autologous BCM comprised of expanded and differentiated B lymphocyte lineage cells genetically engineered ex vivo to secrete FIX-Padua.

Impact of yoga on pulmonary functions in clinical population: A systematic review and meta-analysis of randomized controlled trials (RCTs).

This study aims to investigate the impact of yoga practice on pulmonary and respiratory functions in clinical populations. A thorough search was carried out in the Cochrane Library, PubMed, Science Direct databases, and Google Scholar, using the keywords "Yog∗" and "pulmonary functions", covering the period from January 2010 to December 2022. Studies that aligned with PRISMA recommendations were included.