Development of a certified reference material for per- and polyfluoroalkyl substances (PFAS) in textiles.

Per- and polyfluoroalkyl substances (PFASs) are a large group of emerging organic pollutants that contaminate the environment, food, and consumer products. Textiles and other outdoor products are a major source of PFAS exposure due to their water-repellent impregnations. Determination of PFASs in textiles is increasingly important for enhancing their contribution to the circular economy.

Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancer.

High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for timely detection and development of effective treatment strategies. We performed and integrated spatial cell-type resolved proteomics and paired transcriptomics across 25 women with precursor lesions of the fallopian tube and/or HGSC.

Left atrial epicardial adipose tissue volume quantification by CMR aids identification of patients at low risk for left atrial cardiomyopathy.

Background And Aims: The pathophysiologic concept of atrial fibrillation (AF) has evolved towards defining atrial cardiomyopathy, recognizing inflammation-mediated remodeling of the left atrium (LA) as a source for arrhythmogenesis. One feature of atrial cardiomyopathy is the development of fibrosis, with low-voltage zones (LVZ) identified by invasive electroanatomic mapping as an accepted surrogate parameter. A mediator of pathological remodeling is epicardial adipose tissue (EAT).

Diagnostic approach to swinepox virus infection in a German 2-site swine production unit.

In 2008, nearly 50% of weaned piglets at a German 2-site production unit in Saxony-Anhalt had skin lesions 1-2 wk after relocation into the nursery. First clinical signs were maculae, followed by papules, pustules, and finally crusts, distributed over the dorsal and lateral body flank. Tentative clinical diagnosis was an infection with swinepox virus (SWPV; family , taxon species ).

National, regional, and global statistics on alcohol consumption and associated burden of disease 2000-20: a modelling study and comparative risk assessment.

Background: Data on alcohol consumption and associated health harms are essential to evaluate progress in achieving global health goals. This study aims to estimate global alcohol consumption from 2000 to 2020, and the global burden of alcohol-attributable harms from 2000 to 2019.

Methods: In this global analysis, adult per capita consumption data estimates were modelled on the basis of sales, survey, and traveller data.