Budd-Chiari syndrome is a rare disorder characterized by hepatic vein obstruction, with an incidence of 1 in 100,000. It can be diagnosed through imaging studies and initially managed with anticoagulants. Acute Budd-Chiari syndrome can be treated with thrombolysis to dissolve blood clots obstructing hepatic veins.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) is a major global health issue projected to exceed 700 million cases by 2045. In Malaysia, T2DM prevalence has risen, with notable ethnic disparities. The gut microbiota's role in T2DM pathogenesis is well recognized, yet its composition in Malaysia's ethnically diverse population remains underexplored.
View Article and Find Full Text PDFYoung-onset diabetes (YOD) is characterised by unique diagnostic and management challenges more pronounced in resource-limited settings like Sri Lanka. We aimed to ascertain the prevalence, patterns and characteristics of YOD in Sri Lanka and describe the state of care. Retrospective review of baseline data of all patients enrolled in the prospective multicentre Database for Young-Onset Diabetes, Sri Lanka (DYOD-SL), was performed, from April 2021 to April 2023.
View Article and Find Full Text PDFBMC Endocr Disord
December 2024
Background: Reninoma is a rare cause of secondary hypertension, which can be cured with surgery if identified early before any target organ damage occurs. It leads to hypokalaemia and hypertension and typically responds well to treatment with renin-angiotensin-aldosterone system blockers. However, confirmation of the diagnosis and the localisation of this rare culprit lesion can be challenging.
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