The Occurrence of Obstructive Sleep Apnea and Its Association With Alzheimer Dementia in Medicaid-Enrolled Adults With Down Syndrome, 2011-2019.

Down syndrome is a condition caused by trisomy of chromosome 21 and is the most common genetic cause of intellectual disability. Due to distinct body and facial morphology, people with Down syndrome appear to be at increased risk for obstructive sleep apnea (OSA). Additionally, adults with Down syndrome are at increased risk for Alzheimer dementia at younger ages than the general population, and OSA has been identified as a risk factor for Alzheimer dementia in the general population.

Antimicrobial prescribing guidelines for horses in Australia.

The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses. While antimicrobials are commonly used to treat equine infections, complications with therapy are also relatively common.

Understanding the role of caregiver factors on ACE changes between male and female adolescents in Kinshasa, DRC: A five-wave linked longitudinal panel study.

Background: Adverse Childhood Experiences (ACEs) are traumatic events occurring from ages 0-17 with adolescence a particularly vulnerable period for increased ACEs exposure.

Objectives: This study examines the role of caregivers in shaping ACE changes over time and how these influences differ by sex.

Participants & Setting: Data were drawn from 1450 adolescents (1083 in-school, 367 out-of-school) in two under-resourced communes of Kinshasa, Democratic Republic of Congo.

Copromotion across commercial determinants of health: content analysis of smokeless tobacco social media messages referencing alcohol, 2016-2021.

Objective: The goal of this study is to analyse the amount and content of alcohol-themed smokeless tobacco (ATST) messages on social media, characterise major themes and identify key sources of these messages. These insights are crucial for understanding the tobacco and alcohol industries' marketing strategies and informing effective tobacco control policies.

Methods: We analysed 777 336 smokeless tobacco-relevant tweets from August 2016 to October 2021 and identified 36 804 (4.

Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites.

Frontline drug treatments for malaria are at risk of failing due to emerging resistance, meanwhile drugs used to treat toxoplasmosis have suboptimal efficacy and safety. As demonstrated by the success of clinically used antiparasitic drugs, the diverse structural complexity and biological activity of natural products holds great potential for drug discovery and development, to address the need for new compounds with novel mechanisms. Here we screened the BioAustralis Discovery Plates Series I library, a collection of 812 microbial natural product compounds including rare microbial metabolites, against Plasmodium falciparum erythrocytic stage and Toxoplasma gondii tachyzoite parasites.