Risk Factors for Brucellosis Relapse and Focal Complications: A Nine-Year Multicenter Study in an Endemic Region.

Objectives: Brucellosis remains a significant zoonotic disease in endemic regions, with relapse and focal complications posing significant clinical challenges. This study aimed to identify risk factors associated with brucellosis relapse and focal disease in North Khorasan, Iran, over a nine-year period.

Methods: A retrospective analysis was conducted on 2,568 confirmed brucellosis cases from 2015 to 2024, using data from multiple centers.

Nanomedicine Solutions for Inhibiting Anastasis and Inducing Apoptosis to Mitigate Relapse in Treatment-Resistant Cancers.

Cancer is a leading cause of global mortality, significantly impacted by treatment resistance and the toxicity of conventional therapies like chemotherapy and radiation. Recent studies show that anastasis-the recovery of cells from near-death states-as a key mechanism promoting cancer relapse and apoptosis resistance. During anastasis, stress-induced caspase activation allows cancer cells to survive, increase chemoresistance, and enhance metastatic potential.

Genotypic and Phenotypic Investigation of Clinical Aspergillus isolates from Iran Indicates Nosocomial Transmission Events of Aspergillus flavus.

Aspergillosis is one of the most common human fungal infections. The invasive form of this infectious disease has high mortality rates. Moreover, antifungal resistance has been increasing, thereby limiting treatment options.

Clinical outcomes of transcatheter aortic valve replacement in patients with radiation-induced aortic stenosis: a systematic review and meta-analysis.

Background: Transcatheter aortic valve replacement (TAVR) is an effective treatment for severe aortic stenosis, particularly in high-risk patients unsuitable for surgical aortic valve replacement (SAVR). However, the efficacy of TAVR in patients with radiation-induced aortic stenosis remains uncertain and controversial. This meta-analysis evaluates clinical outcomes of TAVR in patients with prior chest radiation (C-XRT).

Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis.

Candida onychomycosis is a common fungal nail infection where treatment efficacy can be compromised by antifungal resistance. This study investigates the role of efflux pump genes (CDR1, CDR2, and MDR1) and biofilm-associated genes (ALS1, ALS3) in Candida albicans isolates classified as resistant to itraconazole from patients with onychomycosis. Ten itraconazole-resistant and 10 sensitive isolates were collected for efflux pump and biofilm-associated gene expression analysis by Real-Time PCR methods.