Cobalamin and iron deficiency still presents a challenge in hereditary hemorrhagic telangiectasia.

Hereditary hemorrhagic telangiectasia (HHT) leads to fragile blood vessels, causing frequent bleeding and anemia. Treatment mainly addresses iron levels and substitution. Although cobalamin (vitamin B12) is routinely tested in chronic anemia, its role in HHT has not been studied until now.

Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes.

Secretory proteins aggregate into non-soluble dense-core granules in recycling endosome-like compartments prior to regulated release. By contrast, aberrantly processed, secreted amyloid-β (Aβ) peptides derived from amyloid precursor protein (APP) form pathological extracellular amyloidogenic aggregations in late-stage Alzheimer's disease (AD). By examining living Drosophila prostate-like secondary cells, we show that both APP and Aβ peptides affect normal biogenesis of dense-core granules.

Conceptualization of Clinical Reasoning in Physical Therapy.

Clinical reasoning is a cornerstone of physical therapist education, yet current frameworks often fail to capture its complexity and holistic nature. Traditional approaches primarily emphasize cognitive aspects, overlooking the interconnected and multifaceted components of reasoning. This EduGraphic serves as a valuable tool for both didactic and clinical educators, providing a comprehensive visual representation that makes the depth and breadth of clinical reasoning explicit to learners.

Comparing a Model of Augmented Postpartum Primary Care to Usual Care in an Urban Medical Center.

Background: The US faces a maternal health crisis and struggles to deliver recommended postpartum care. In some populations, less than half of mothers attend a postpartum visit.

Objective: To determine if a two-generation (Two-Gen) model of interdisciplinary, postpartum primary care was associated with increased visit attendance for postpartum care, primary care, and behavioral health.

Reemerging/Notifiable Diseases to Watch.

Reemerging and notifiable diseases of cattle and bison continue to pose potential risks to their health and lives and affecting production and the livelihoods of producers. It is essential to understand the clinical presentation of these diseases to watch for possible incursions and infections and to immediately report your suspicions to your State and Federal Animal Health Officials. Three of these reemerging and notifiable diseases of cattle and bison, malignant catarrhal fever, bluetongue virus, and New World screwworm, are presented in this article for increased awareness to consider as a differential if examinations present suggestive clinical signs.