NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release.

Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic bodies (ApoBDs) to promote dead cell clearance, or otherwise proceed to an inflammatory, lytic outcome (i.e.

Combining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial.

This open-label clinical trial examined the preliminary efficacy of combining a course of 6 ketamine infusions with a brief, evidence-based exposure-based psychotherapy-written exposure therapy (WET)-in patients with chronic posttraumatic stress disorder (PTSD). The trial was conducted between June 2021 and October 2023. Patients with chronic PTSD and high-moderate to severe symptom levels received 6 intravenous ketamine infusions (0.

The future of scientific labs: how we are making our research more sustainable.

The need for climate action is becoming increasingly urgent, and research labs need to be part of the solution. Scientific labs consume large amounts of energy and water and produce significant waste. Globally, scientific research generates over 5.

Effects of a synthetic analog of the bovine appeasing pheromone on the overall welfare of dairy calves from birth through weaning.

Environmental enrichment in the form of synthetic analogs of appeasing pheromones have shown promising results in improving the welfare of domestic animals, including dogs, pigs, horses, and cattle. The main objective of this study was to determine if the use of the bovine appeasing pheromone (BAP) would improve the welfare of dairy calves; therefore, in this randomized controlled trial, 72 Holstein Friesian dairy calves were housed in individual hutches after birth and were randomly allocated to receive BAP or a placebo once every 2 wk from birth through weaning. After weaning, calves were moved to group hutches according to treatment for 4 additional weeks.

Human-animal interactions and machine-animal interactions in animals under human care: A summary of stakeholder and researcher perceptions and future directions.

Animals under human care are exposed to a potentially large range of both familiar and unfamiliar humans. Human-animal interactions vary across settings, and individuals, with the nature of the interaction being affected by a suite of different intrinsic and extrinsic factors. These interactions can be described as positive, negative or neutral.