A long noncoding RNA-based serum signature predicts ado-trastuzumab emtansine (T-DM1) treatment benefit in HER2+ metastatic breast cancer patients: a multicenter cohort study.

Ado-trastuzumab is considered a standard treatment for patients with HER2+ metastatic breast cancer (mBC). Current clinical practices do not reliably predict therapeutic outcomes for patients who are refractory to therapy. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and therapeutic resistance, and the use of lncRNAs as tumor biomarkers is becoming more common in other diseases.

Outcomes of a Second Run of Extracorporeal Membrane Oxygenation in Neonates: A Propensity Score Matched Analysis of a Nationwide Registry.

This study analyzed the outcomes of neonates undergoing a second run of extracorporeal membrane oxygenation (ECMO) to determine whether there is a benefit to a repeated run. We used Extracorporeal Life Support Organization data to compare neonates undergoing a single versus two runs of ECMO from 2009 to 2019. Baseline characteristics of single-run patients were compared with the first run in two-run patients to identify clinical predictors of a second run of ECMO.

Comparative assessment of composting methods for the organic fraction of municipal solid waste: physicochemical insights.

Changes in consumption patterns, urbanization, and industrialization have led to the generation of large volumes of municipal solid waste (MSW), posing threats to environmental sustainability. This study aimed to compost the organic fraction of municipal solid waste (OFMSW) using three composting methods: windrow (WC), pit (PC), and drum composting (DC). Distilled water was used in compost preparation and sample analysis.

Carbonate esters as green alternatives in chromatographic separations.

Background: Carbonate esters are polar aprotic solvents that can be used to replace polar solvents: methanol, acetonitrile, or even apolar solvents in the mobile phases for liquid chromatography. Dimethyl, diethyl, and propylene carbonates (DMC, DEC, and PC) are not fully soluble in water.

Results: Twelve volume phase diagrams of water, the three carbonates, and methanol, ethanol, propanol, and acetonitrile were determined.

Altermagnetic Band Splitting in 10 nm Epitaxial CrSb Thin Films.

Altermagnets are a newly identified family of collinear antiferromagnets with a momentum-dependent spin-split band structure of non-relativistic origin, derived from spin-group symmetry-protected crystal structures. Among candidate altermagnets, CrSb is attractive for potential applications because of a large spin-splitting near the Fermi level and a high Néel transition temperature of around 700 K. Molecular beam epitaxy is used to synthesize CrSb (0001) thin films with thicknesses ranging from 10 to 100 nm.