Integrating hematological profile and biomarker analysis for metals and metalloids ecotoxicological assessment on Wallago catfish and Indian carp health in Head Siphon, Mailsi, Pakistan.

Bioaccumulation of metals and metalloids in marine environments poses a significant risk to both human and aquatic health, with seasonal fluctuations substantially influencing its dynamics and magnitude. This study investigated the impact of metals and metalloids exposure on the health of Wallago attu (Wallago catfish) and Catla catla (Indian carp) inhabiting the Head Siphon, Mailsi, Pakistan. This study involved the seasonal (May 2022, October 2022, April 2023) assessment of physicochemical properties and the concentrations of several metals and metalloids-copper (Cu), chromium (Cr), arsenic (As), cadmium (Cd), nickel (Ni), zinc (Zn), and iron (Fe)-in water samples.

Mapping the global research landscape of tirzepatide: a bibliometric analysis of trends, collaborations, and emerging themes in obesity and diabetes managements.

Tirzepatide, a dual GIP/GLP-1 receptor agonist, shows promise in managing obesity and type 2 diabetes. This bibliometric analysis maps its research landscape, identifying trends, collaborations, and emerging themes to guide future investigations. A structured search of the Scopus database was performed using the keywords "tirzepatide" in titles or abstracts, limited to English-language original articles.

A SERS-Based Antibody-Aptamer Sandwich Assay for Extracellular Vesicle-Associated Tau Detection Using Gold Nanoparticles.

Extracellular vesicles (EVs) have emerged as sources of promising, minimally invasive biomarkers for diagnosing and monitoring diseases like Alzheimer's. Using EVs as a source of biomarkers for neurological diseases is highly relevant because they can carry pathogenic proteins, such as tau and amyloid-β, across the blood-brain barrier and can be easily accessed and collected since they are available in almost all biofluids, including blood, urine, and saliva. Here, a bioanalytical antibody-aptamer sandwich assay detection using surface-enhanced Raman spectroscopy (SERS) is developed to quantify the expression of EV-associated tau.