Safety and Efficacy Assessment of Trastuzumab Emtansine in Indian Patients With Human Epidermal Growth Factor Receptor 2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer Previously Treated With Trastuzumab and a Taxane: An Open-Label, Single-Arm, Phase IV Study.

Introduction: Trastuzumab emtansine (T-DM1), an antibody-drug conjugate, targets tumor cells overexpressing human epidermal growth factor receptor 2 (HER2). This single-arm, phase IV study assessed the safety and efficacy of T-DM1 in Indian patients with HER2-positive, locally advanced, or metastatic breast cancer previously treated with trastuzumab and a taxane.

Methods: Patients received T-DM1 (3.

Electrochemical Oxidative Ring Opening of 1-Acetylindoline-3-one to Access α-Ketoamides.

The synthesis of α-ketoamides through oxidative ring opening of 1-acetylindoline-3-one under electrochemical conditions is reported. In an undivided cell, the reaction proceeds via the formation of an iminium ion intermediate, nucleophilic attack by a hydroxide ion, and subsequent ring opening through pre-existing C-N bond cleavage. The reaction in the presence of HO confirms that the amidic oxygen originated from the moisture present in the medium.

Triazole-Pyrimidine Hybrids as EGFR Inhibitors via Synthesis, In Silico, In Vitro, and In Vivo Evaluation as Anticancer Agents.

The epidermal growth factor receptor (EGFR) is a common diver gene for lung cancer (NSCLC), which leads to an increasing death rate worldwide. This study reports the design, synthesis, and biological evaluation of triazole-clubbed pyrimidine derivatives (RDa-RDm) as potential anticancer agents. Thirteen compounds were synthesized and screened against the A549 lung cancer cell line.

Evaluation and Comparison of the Precision of Dental Implant Impressions and the Marginal Fit of Crowns Using Conventional and Digital Methods: A Clinical Study.

Background Accurate impressions are essential for the long-term success of implant-supported restorations. Both conventional and digital techniques are routinely used in clinical implantology, each with its own advantages and limitations. This study aimed to evaluate and compare the precision of digital and conventional implant impressions and compare the marginal fit of crowns obtained from digital impressions and those obtained from conventional impressions.

The Impact of Two Cordless Retraction Materials on Inflammatory Biomarkers Interleukin-1 Beta and Tumor Necrosis Factor-Alpha in Gingival Crevicular Fluid: An In-Vivo Study.

Introduction: This study aimed to evaluate and compare the inflammatory responses of two cordless gingival retraction systems by assessing the levels of interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF). The objectives were to measure IL-1β and TNF-α levels before and after retraction using kaolin-based and polyvinyl acetate-based cordless gingival retraction materials at baseline, 1 h, and 24 h, and to compare the inflammatory profiles of these materials.

Materials And Methods: This in-vivo comparative study used a split-mouth design, with each of the 10 enrolled patients serving as their own control by receiving both kaolin-based paste (Traxodent®, Premier Dental Products, Plymouth Meeting, PA, USA) and polyvinyl acetate-based strip (Merocel®, Medtronic, Minneapolis, MN, USA) on different endodontically treated teeth requiring full-coverage crowns, thereby minimizing interindividual variability.