Cancer-associated fibroblasts as a potential therapeutic target for thyroid cancers.

Thyroid cancer, a prevalent endocrine malignancy, is influenced by its tumor microenvironment (TME), with cancer-associated fibroblasts (CAFs) playing a pivotal role in disease progression. Molecularly, CAFs orchestrate a pro-tumorigenic niche via cytokine secretion and extracellular matrix (ECM) stiffening, underscoring their targetability. Therapeutic strategies, including small molecule inhibitor-based therapies, immune-based therapies, nanoparticle-based approaches, and combination regimens, have been evaluated for their efficacy in disrupting CAF functionality.

A systematic review and modelling insights of factors impacting measles vaccine effectiveness, efficacy and immunogenicity.

Introduction: Outbreaks of measles have been frequently reported despite the availability of an effective vaccine. In this systematic review we examine the potential factors that could impact the effectiveness, efficacy and immunogenicity of the measles vaccine (MV) in children.

Methods: We conducted a literature search using PubMed and Google Scholar for primary articles published between January 2010 and April 2025.

Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review.

Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a naturally occurring polyphenol molecule. It is lipophilic and has demonstrated and therapeutic effects through multiple pathways. Extensive studies on its pharmacological properties have shown its anti-inflammatory, antioxidant, antinociceptive, antimicrobial, antiparasitic, antimalarial, and wound-healing properties.

Suprathreshold dosing of selective serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: A case series.

Supratherapeutic dosing of selective serotonin reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) is an area of clinical interest, particularly for treatment-resistant cases. Standard SSRI doses often provide insufficient symptom relief, prompting clinicians to explore higher-than-recommended doses. Evidence suggests that supratherapeutic dosing can enhance serotonergic activity, potentially improving treatment response.

Role of kinematic constraints in the time reversal symmetry breaking of a model active matter.

Active-matter systems are inherently out-of-equilibrium and perform mechanical work by utilizing their internal energy sources. Breakdown of time-reversal symmetry (BTRS) is a hallmark of such dissipative nonequilibrium dynamics. We introduce a robust, experimentally accessible, noninvasive, quantitative measure of BTRS in terms of the Kullback-Leibler divergence in collision events, demonstrated in our novel artificial active matter, comprised of battery-powered spherical rolling robots whose energetics in different modes of motion can be measured with high precision.