Publications by authors named "S Ganeshkumar"
Uterine fibroids, benign tumors of the smooth muscle layer of the uterus, plague approximately 80% of the female population by age 50. While there have been efforts to understand the mechanism behind this pathophysiology, it largely remains unclear. Lack of preclinical animal models that recapitulate aberrant steroid hormone pathways in UL has significantly hampered the development of long-term hormonal therapies for uterine fibroids.
View Article and Find Full Text PDFSuccessful embryo implantation requires coordinated changes in the uterine luminal epithelium, including structural adaptations, apical-basal polarity shifts, intrauterine fluid resorption, and cellular communication. Planar cell polarity proteins, essential for cell organization, are understudied in the context of uterine physiology and implantation. PRICKLE proteins, components of PCP, are suggested to play critical roles in epithelial polarization and tissue morphogenesis.
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- Uterine leiomyomas (UL) are common benign tumors affecting over 75% of reproductive-age women, causing symptoms like pelvic pain and reproductive dysfunction, but lack effective long-term treatments, leading to high hysterectomy rates.
- The loss of REST/NRSF in the myometrium has been linked to UL development, and the protein PRICKLE1 is crucial for REST's function and Wnt/PCP signaling, areas that are not fully understood in relation to UL.
- Research involving the deletion of Prickle1 in mouse models showed a UL phenotype with changes in collagen expression and ECM deposition, paving the way for better understanding UL and potential new therapies.
Article Synopsis
- Successful embryo implantation relies on changes in the uterine epithelium, involving structural adaptations and cell communication, with PCP proteins like PRICKLE playing a crucial yet understudied role.
- Disruption of PRICKLE1 in the endometrial epithelium of mice led to decreased embryo implantation and fertility, revealing its importance in maintaining uterine architecture.
- The study highlights PRICKLE1’s role in cell division and other physiological processes critical for embryo implantation and overall reproductive success.
This research aims to investigate the ballistic resistance of base material (BM)and "Friction Stir Welded (FSW)", AA5083 aluminum alloy. The primary objective was to build a finite element model to predict kinetic energy absorption and target deformation under single and multiple projectile impact conditions. This study employed 7.
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