Identification of Common Genes for Neuropathic Pain and Parkinson's Disease Based on Bioinformatics Analysis and Their Potential Value in the Diagnosis of Neuropathic Pain.

Background: Parkinson's disease (PD) is a common neurodegenerative disorder of the central nervous system. Neuropathic pain (NP) is a type of symptom that is often overlooked but significantly affects the quality of life of patients. Its etiology is complex, and the specific molecular mechanism is still unclear.

Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology.

Atherosclerosis (AS) is increasingly recognized as a disease influenced not only by lipid metabolism and inflammation but also by the gut microbiota and their bioactive metabolites. Isoquercitrin (ISO), a natural flavonoid with food-medicine homology, has shown promising antiatherosclerotic potential, yet its underlying mechanisms remain unclear. In this study, ISO administration significantly reduced plaque burden, improved lipid profiles, and restored gut microbial balance by enriching beneficial taxa, such as , , and .

Unraveling the mechanisms of selenite reduction and selenium nanoparticle biosynthesis in the highly selenite-tolerant yeast Trichosporon asahii I30.

Selenite contamination poses a significant environmental risk due to its high toxicity, mobility, and bioavailability, and further threatens ecological stability and human health via biological accumulation in trophic chains. Microbial transformation of selenite into selenium nanoparticles (SeNPs) represents a promising and sustainable bioremediation strategy. However, the underlying mechanisms in environmentally prevalent yeasts remain largely uncharacterized.

Unveiling the culturable and non-culturable yeast biodiversity in chaste honey produced by the sympatric Apis cerana and Apis mellifera from eastern China.

Honey's unique physicochemical properties create a restrictive environment for most microorganisms, yet support the specialized osmotolerant yeasts with significant ecological roles and biotechnological potential. In this study, we employed an integrated culture-dependent and culture-independent approach to systematically characterize yeast communities in sympatric monofloral chaste (Vitex agnus-castus) honeys from Apis cerana and Apis mellifera colonies in Qingdao, East China. Results consistently showed that A.