Availability of anti-rabies vaccine and rabies immunoglobulin in Indian health facilities: a nationwide cross-sectional health facility survey.

Background: Ensuring the uninterrupted availability of the anti-rabies vaccine (ARV) and rabies immunoglobulin (RIG) in health facilities is crucial to achieve the global target of zero dog-mediated human rabies deaths by 2030. This study aimed to estimate the availability of ARV and RIG across health facilities in India.

Methods: We conducted a nationwide health facility-based, cross-sectional study across 60 districts selected by multistage probability sampling from 15 Indian states.

India's 2021 differentiated TB care guidance: Is it feasible to implement and act upon?

Background: In 2021, India's national tuberculosis (TB) elimination programme recommended severity assessment using 16 indicators (involving clinical, laboratory and radiological assessment) for all TB patients at diagnosis. Patients with a total score more than one or emergency criteria were eligible for referral and inpatient care (called as severely ill). This guidance is yet to be implemented statewide in India.

Survival and quality-of-life in mucormycosis: a multicentric ambispective cohort study.

Objectives: We aimed to evaluate long-term survival and identify predictors of mortality among patients hospitalized with mucormycosis.

Methods: This prospective, multicentre cohort study included patients hospitalized for mucormycosis across 26 sites in India from March to July 2021. Follow-up data were collected at 1-, 3-, 6-, and 12-month intervals post-discharge through telephonic or in-person interviews with patients or caregivers.

In-vivo immunocompatibility and induced regenerative potential of silk fibroin modified decellularized porcine liver scaffolds in rat subcutaneous and full-thickness abdominal wall defect models.

For reconstructive surgical applications, humoral and cell-mediated immune response to scaffolds is important in determining its structural and functional integration and performance. A decellularized porcine liver matrix(DPL) mechanically augmented with impregnating silk fibroin(SF100DPL) and silk fibroin-gelatin blends(SFG5050DPL and SFG3070DPL) following citric acid crosslinking were evaluated in-vitro and in-vivo (subcutaneous and abdominal wall defect models) in comparison to unmodified DPL. Ensuring the preservation of glycosaminoglycan and the potential to induce cell migration in L929 cell line, the host immunocompatibility of the scaffolds was confirmed by implanting sub-cutaneously in rat.