Gaps in immunization coverage at school entry and after two years of school attendance among immigrant and refugee children in Ontario, Canada.

Background: Foreign-born children may face greater barriers to accessing routine immunizations in Canada or their country of birth, but provincial surveillance data on immigration status are lacking. Using our provincial immunization repository linked to administrative data, we assessed immunization coverage among immigrant and refugee children in Ontario, Canada, compared with Ontario-born children and identified factors associated with being up-to-date (UTD).

Methods: We conducted a retrospective cohort study of children entering school during the 2012/13-2014/15 school years.

Meta-analysis examining fetal sex-specific placental DNA methylation intensities and estimated cell composition post in vitro fertilization.

Infertility impacts up to 17.5% of reproductive-aged couples worldwide. To aid in conception, many couples turn to assisted reproductive technology, such as IVF.

Genome topology analysis and transcriptomics of human osteoclasts reveals enhancer-promoter interactions at loci for bone traits and diseases.

Genome-wide association studies (GWAS) relevant to osteoporosis have identified hundreds of loci; however, understanding how these variants influence the phenotype is complicated because most reside in non-coding DNA sequence that serves as transcriptional enhancers and repressors. To advance knowledge on these regulatory elements in osteoclasts (OCs), we performed Micro-C analysis, which informs on the genome topology of these cells and integrated the results with transcriptome and GWAS data to further define loci linked to BMD. Using blood cells isolated from 4 healthy participants aged 31-61 yr, we cultured OC in vitro and generated a Micro-C chromatin conformation capture dataset.

Children's Satiety Responsiveness Moderates the Association between Food Reinforcement and Eating in the Absence of Hunger.

The reinforcing value of food, a measure of motivation to obtain food, is associated with obesity in children. However, the extent to which food reinforcement predicts children's intake under different contexts (i.e.