Whole transcriptome analysis identifies fusion as a novel biomarker in metastatic colorectal cancer.

Background: Colorectal cancer (CRC) is a complex, heterogeneous disease characterized by frequent relapses and metastasis. Previous studies have reported that the invasion and progression of CRC in several cases can be controlled by targeting fusion genes. This study aimed to screen for potent fusion transcripts as potential molecular biomarkers and therapeutic targets for metastatic CRC (mCRC) using an approach.

Eugenol Promotes Immune Function and Survival Rate in Cecal Ligation Puncture Induced Sepsis Rat Model by Targeting A2A Receptor to Regulate Oxidative Stress Pathway.

This study investigates the potential protective effects of eugenol on cecal ligation puncture (CLP) induced sepsis rat model. CLP was used to induce sepsis in rats and then treated with eugenol at doses of 25 and 50 mg/kg, i.p.

Don't Go Vaping My Heart: E-cigarette Exposure During Pregnancy Promotes Peripartum Ventricular Arrhythmias and Sympathetic Dominance.

Electronic cigarettes (E-cigs) are commonly presumed as a safer alternative to traditional cigarettes despite limited understanding of their health risks. This assumption may lead people, especially those in at-risk groups, to switch from traditional cigarettes to e-cigs, or to use e-cigs as their first form of nicotine consumption. Despite that pregnancy increases susceptibility to adverse cardiac events, a considerable fraction of pregnant women use e-cigs during gestation and postpartum.

A novel functional screening method for generation of a synthetic microbial community: Case study with control of Fusarium wilt in pigeonpea.

Conventional methods to combat phytopathogens have ecological implications: chemical fertilizers pollute the environment, while bioinoculants are often inconsistent under field conditions. Microbiome-assisted rhizosphere engineering aims to re-structure the rhizosphere microbiome to promote plant growth and/or mitigate stress. This study employs a strategy based on rhizosphere engineering to combat stress caused by Fusarium udum in Cajanus cajan, by generating synthetic microbial communities (SMCs).