Oxophilic Sites Mediated Dynamic Oxygen Replenishment to Stabilize Lattice Oxygen Catalysis in Acidic Water Oxidation.

Developing efficient and durable catalysts for the oxygen evolution reaction (OER) in acidic media is essential for advancing proton exchange membrane water electrolysis (PEMWE). However, catalyst instability caused by lattice oxygen (O) depletion and metal dissolution remains a critical barrier. Here, we propose an oxophilic-site-mediated dynamic oxygen replenishment mechanism (DORM), in which O actively participates in O-O bond formation and is continuously refilled by water-derived species.

Advancements in CRISPR-Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens.

CRISPR-Cas systems have been explored for targeted genome editing of several organisms. It is rapid, cost-effective, specific, and versatile technology. It requires expression of multidomain single Cas9 protein and single guide RNA (sgRNA) that targets desired nucleic acids in the presence of a protospacer adjacent motif (PAM).

Impact of CAR T cell therapy on thymus size in children and young adults with acute lymphoblastic leukemia.

Chimeric Antigen Receptor (CAR) T-cell therapy has demonstrated efficacy in children and young adult patients with acute lymphoblastic leukemia (ALL). The purpose of our study was to investigate thymus size changes after CAR T-cell therapy, explore the associated clinical conditions, and assess survival differences of patients who underwent CAR T-cell therapy, we conducted a single-center retrospective study of children and young adult patients who underwent CAR T-cell therapy for ALL between April 2015 and October 2023.We measured the volume of the thymus on pre- and post-CAR T-cell chest CT scans of 20 patients (median [IQR] age, 18[11] years; 11 females).

Ubiquitin specific protease 7 deubiquitinates and regulates Aurora B-mediated cytokinesis.

Aurora B is a widely studied mitotic checkpoint kinase that forms a part of the chromosomal passenger complex. The entry to and exit from mitosis are exquisitely controlled by Aurora B proteins, which regulate mitotic phases including chromosomal condensation, segregation, and cytokinesis, ensuring faithful propagation of daughter cells. Abnormal regulation of Aurora B proteins during the cell cycle can cause increased chromosomal segregation errors and ultimately lead to cancer.

Modification, Degradation, and Mitigation of Perfluorosulfonic Acid Proton Exchange Membranes for Fuel Cells: A Review.

Proton exchange membrane fuel cells (PEMFCs) offer a transformative solution to mitigate climate change by reducing carbon emissions and global carbon footprints. Perfluorosulfonic acid (PFSA) membranes are crucial components of fuel cell stacks, exhibiting superior proton conductivity, mechanical strength, and chemical stability under hydrated conditions. However, these membranes face significant challenges, including low thermal and chemical steadiness, insufficient mechanical strength, high production costs, and hasty degradation at elevated temperatures during long-term operation.