Effects of unsupervised walking on walk performance and functional mobility in individuals with chronic stroke: a blind randomized clinical trial.

Background: What are the effects of walking training on the ground in an unsupervised manner and with different weekly durations after chronic stroke?

Objective: To compare the effects of unsupervised walking for 150 and 300 minutes per week on walking performance, speed, and functional mobility in individuals with chronic stroke.

Design And Setting: Randomized clinical trial was conducted at Rede Sarah Rehabilitation Hospital (São Luís, Brazil).

Methods: Individuals included (n = 40) were assessed using the 6-minute walk test (6MWT), functional mobility using the Timed Up and Go (TUG) test, and the Five Times Sit to Stand Test (FTSST).

Thermostable unit solid dose formulations for subcutaneous administration of DNA vaccines.

The coronavirus disease 2019 pandemic has highlighted the critical need for thermostable vaccines to ensure equitable distribution and accessibility, particularly in regions lacking cold chain infrastructure. Here we present a thermostable, solid dose DNA vaccine (SDV) platform for subcutaneous delivery, based on a sugar-sugar alcohol-polymer formulation manufactured via lyophilization and compaction. Using luciferase-expressing plasmid as a model, we demonstrate that subcutaneous vaccination with SDV formulation of C57BL/6 mice results in efficient and durable transgene expression .

Investigation of the Antimicrobial Properties of Gerês Propolis in Bacteria Isolated from Companion Animals and Safety Profile Characterization Using the Model.

Propolis, also known as bee glue, is a natural resinous mixture produced by Western honeybees and has long been recognized for its potential therapeutic properties. Recent research has focused on its diverse bioactivities, particularly its antimicrobial effects against a broad spectrum of microorganisms, including human but also animal pathogens. However, further investigation is required to fully elucidate the pharmacological properties and potential toxicity of propolis to support its broader application.

The currently knowledge on toxicity of TiO nanoparticles in microalgae: A systematic review.

Titanium dioxide (TiO₂) nanoparticles (NPs) are widely applied across various industries and research fields, raising growing concerns regarding their potential as environmental pollutants. This work presents a systematic review of the toxicity of TiO₂ NPs to microalgae, providing a critical synthesis of current findings and identifying key gaps to guide future research. The analysis reveals that numerous variables associated with growth inhibition assays-such as NPs characteristics and experimental conditions-substantially influence toxicity outcomes, complicating direct comparisons across studies.