Publications by authors named "Ryuhei Miyake"
Article Synopsis
- - Increased lactate levels from glycolysis are being studied as potential markers for metabolic changes in neurons, linked to a drop in brain pH, which has been associated with various neuropsychiatric disorders like schizophrenia and autism.
- - Research shows that these pH and lactate changes are common across different animal models, including those for depression, epilepsy, and Alzheimer's disease, though findings vary, particularly within the autism spectrum.
- - A large-scale analysis indicated that higher lactate levels correlate with worse working memory performance, suggesting that altered brain chemistry might reflect underlying conditions across multiple disorders.
Effect of brain acidification on depression-related behaviors in diabetes mellitus.
Front Psychiatry
November 2023
Major depressive disorder (depression) is a leading cause of disability. The severity of depression is affected by many factors, one of which being comorbidity with diabetes mellitus (DM). The comorbidity of depression with DM is a major public health concern due to the high incidence of both conditions and their mutually exacerbating pathophysiology.
View Article and Find Full Text PDFHuman genetics strongly support the involvement of synaptopathy in psychiatric disorders. However, trans-scale causality linking synapse pathology to behavioral changes is lacking. To address this question, we examined the effects of synaptic inputs on dendrites, cells, and behaviors of mice with knockdown of SETD1A and DISC1, which are validated animal models of schizophrenia.
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