Publications by authors named "Ryoko Sekiya"
Objectives: Long-acting cabotegravir plus rilpivirine (CAB+RPV) offers an alternative to daily oral therapy, but real-world data in East Asia remain scarce. This study aims to evaluate the impact of CAB+RPV in people with HIV in Japan, focusing on virological outcomes, treatment continuation and inflammatory markers, providing valuable insight into the use of injectable regimens in clinical practice.
Methods: This multicentre retrospective study analysed routinely collected data from eight HIV centres in Japan on people with HIV who initiated CAB+RPV before January 2024.
Background: The two-drug regimen of dolutegravir/lamivudine (DTG/3TC) is currently an optional antiretroviral therapy (ART). Despite its reported advantages on body weight and lipid profile, the same effects have not yet been reported for Asian population.
Methods: We conducted a single-center retrospective study involving Japanese people living with HIV (PLWH).
Article Synopsis
- A study was conducted on Japanese people living with HIV to compare body weight changes when switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide fumarate (TAF) while on antiretroviral therapy.
- The results showed no significant overall difference in weight gain between TDF and TAF; however, younger patients (<50 years) experienced greater weight gain on TAF compared to older patients.
- The study concludes that while switching to TAF does not generally lead to weight gain, using it alongside dolutegravir (DTG) may correlate with increased weight gain, especially in younger populations.
[Ocular Syphilis Complicated with HIV Infection: A Report of 3 Cases].
Kansenshogaku Zasshi
May 2016
We present 3 cases of ocular syphilis in patients who had been newly diagnosed as having HIV. All the patients had only complained of ophthalmologic symptoms at the time of their initial visit. Treatment with penicillin was successful, resulting in no significant sequelae.
View Article and Find Full Text PDFWe report a case of a 63-year-old HIV-positive Japanese male with a CD4 cell count of 127/μL who was admitted to our hospital because of suspected malignant lymphoma. Initial blood tests revealed anemia, thrombocytopenia, hypoalbuminemia, and hypergammaglobulinemia. Imaging tests revealed a lung nodule, bilateral pleural effusion, hepatosplenomegaly and generalized lymphadenopathy.
View Article and Find Full Text PDFArticle Synopsis
- Autoimmune pancreatitis (AIP) often leads to diabetes mellitus (DM), and this study aimed to assess how steroid therapy affects DM in AIP patients.
- In a study of 69 patients with AIP, 46% had DM, and after three months of steroid treatment, about 54% of these patients showed improvement in their glucose levels.
- The findings suggest that around 60% of DM cases related to AIP respond positively to steroids over time, indicating that significant DM in these patients may warrant steroid therapy. *