Publications by authors named "Ryan P Zimmerman"
BACKGROUND Intramuscular myxomas are rare and benign soft-tissue tumors of uncertain differentiation. Predisposing or precipitating factors have not yet been reported. Activating mutation in GNAS (exons 8 and 9) is detected in >90% of sporadic cases.
View Article and Find Full Text PDFEPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.
Mol Cell Biochem
May 2012
Statins are known clinically by their cholesterol reduction properties through the inhibition of HMG-CoA reductase. There is mounting evidence suggesting a protective role of statins in certain types of cancer, cardiac, and vascular disease through a mechanism that extends beyond their lipid lowering ability. The root mechanism of damage likely involves the inflammatory cascade, specifically compounds known as reactive oxygen species such as the hydroxyl radical.
View Article and Find Full Text PDFArticle Synopsis
- Mesalamine is the recommended first treatment for ulcerative colitis, and studies suggest it may help protect against colorectal cancer, although the exact reason for this protection is not yet clear.
- Researchers found that when mesalamine interacts with copper, it can cause oxidative damage to DNA, indicating a potential mechanism for its anticancer effects.
- The study identified that this reaction generates harmful hydroxyl radicals, leading to DNA strand breaks, highlighting how mesalamine's copper interaction could be both damaging and protective.