Publications by authors named "Ryan D Gillis"
Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice.
J Sport Health Sci
September 2024
Article Synopsis
- Regular exercise has been linked to reduced breast cancer incidence and progression, prompting the study of its underlying mechanisms.
- The research found that exercise, particularly when social interactions are included, can slow down tumor development in specific mouse models of breast cancer, and revealed a potential link between exercise and the secretory protein decorin.
- While higher levels of decorin in tumors correlate with better patient prognoses, the study concluded that simply increasing decorin in circulation through exercise may not directly enhance tumor decorin levels or reduce tumor burden.
Article Synopsis
- Recent studies suggest that propofol-based anesthesia during cancer surgeries may lead to better survival rates compared to inhaled anesthesia, but more research is needed to confirm these results in humans.
- This study used mouse models to investigate whether different anesthetics (propofol vs. sevoflurane) affect cancer recurrence after tumor removal, monitoring outcomes through non-invasive imaging and assessing vascular and immune responses.
- The results showed no significant differences in cancer recurrence or survival between the anesthetic methods, indicating that the type of anesthesia used during surgery may not impact cancer outcomes in these models.
Beta-adrenergic blockade has been associated with improved cancer survival in patients with triple-negative breast cancer (TNBC), but the mechanisms of these effects remain unclear. In clinical epidemiological analyses, we identified a relationship between beta-blocker use and anthracycline chemotherapy in protecting against TNBC progression, disease recurrence, and mortality. We recapitulated the effect of beta-blockade on anthracycline efficacy in xenograft mouse models of TNBC.
View Article and Find Full Text PDFAnesthesia is a routine component of cancer care that is used for diagnostic and therapeutic procedures. The anesthetic technique has recently been implicated in impacting long-term cancer outcomes, possibly through modulation of adrenergic-inflammatory responses that impact cancer cell behavior and immune cell function. Emerging evidence suggests that propofol-based total intravenous anesthesia (TIVA) may be beneficial for long-term cancer outcomes when compared to inhaled volatile anesthesia.
View Article and Find Full Text PDFPurpose: The sympathetic nervous system drives breast cancer progression through β-adrenergic receptor signalling. This discovery has led to the consideration of cardiac β-blocker drugs as novel strategies for anticancer therapies. Carvedilol is a β-blocker used in the management of cardiovascular disorders, anxiety, migraine and chemotherapy-induced cardiotoxicity.
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