Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially originated in China in year 2019 and spread rapidly across the globe within 5 months, causing over 96 million cases of infection and over 2 million deaths. Huge efforts were undertaken to bring the COVID-19 vaccines in clinical development, so that it can be made available at the earliest, if found to be efficacious in the trials. We developed a candidate vaccine ZyCoV-D comprising of a DNA plasmid vector carrying the gene encoding the spike protein (S) of the SARS-CoV-2 virus.

Protective effect of medicinal fungus Xylaria nigripes mycelia extracts against hydrogen peroxide-induced apoptosis in PC12 cells.

Xylaria nigripes ( XN) is a medicinal fungus that was used traditionally as a diuretic, nerve tonic, and for treating insomnia and trauma. In this study, we elucidated possible mechanisms of neuroprotective effects of XN mycelia extracts. XN mycelia were produced by fermentation.

Metabolic engineering of Saccharomyces cerevisiae for improvement in stresses tolerance.

Lignocellulosic biomass is an attractive low-cost feedstock for bioethanol production. During bioethanol production, Saccharomyces cerevisiae, the common used starter, faces several environmental stresses such as aldehydes, glucose, ethanol, high temperature, acid, alkaline and osmotic pressure. The aim of this study was to construct a genetic recombinant S.

A New Schiff Base Chemodosimeter: Selective Colorimetric and Fluorescent Detection of Fe (III) Ion.

A new efficient chemosensor 1 was prepared, for the detection of Fe(3+) in solutions as a colorimetric and fluorescent sensor. The visual and fluorescent behaviors of the receptor toward various metal ions were also explored. The receptor shows exclusive response toward Fe(3+) ions and also distinguishes Fe(3+) from other cations by color change and fluorescence enhancement in hydroalcoholic solution (MeOH/H2O = 9/1, v/v).

A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells.

A new and efficient chemodosimeter for ferric ions has been developed. The visual and fluorescent behaviors of the compound toward various metal ions were investigated: ferric ions are distinguished from other cations by selective color change and unusual fluorescence enhancement in mixed aqueous solution. Fluorescence microscopy experiments showed that this receptor is effective for detection of Fe(3+) in vitro, developing a good image of the biological organelles.