Publications by authors named "Rui-Zhi Chang"
Article Synopsis
- Liver metastases often occur in advanced cancer stages, posing a major clinical challenge due to their complex interactions with immune cells in the liver.
- These immune cells contribute to the growth of metastases by interacting with tumor cells and liver components, creating supportive environments for the tumors.
- Despite current treatments being largely ineffective, researchers are actively investigating new immune-based therapies tailored for patients with liver metastases.
Article Synopsis
- GRIN2A mutations are linked to better responses to immune checkpoint inhibitors (ICIs) in cancer patients.
- A study involving over 2400 patients found that those with GRIN2A mutations had improved clinical outcomes, including higher response rates and longer survival.
- Multiomics analysis showed that these mutations were associated with increased immune activity and tumor characteristics that enhance the effectiveness of ICI therapy.
Article Synopsis
- Advanced hepatocellular carcinoma (HCC) has a poor prognosis, but combined therapies like hepatic artery infusion chemotherapy, lenvatinib, and PD-1 antibodies can improve treatment outcomes, potentially allowing for salvage hepatectomy if conditions are favorable.
- A case study of a 59-year-old man with a large HCC illustrates that genomic analysis indicated he could benefit from aggressive treatment, which led to a positive response after receiving combined therapies.
- Despite initially being deemed unsuitable for surgery due to low future liver remnant volume, additional procedures increased his FLV, enabling a successful right hemi-hepatectomy with no complications or tumor recurrence during a 9-month follow-up.
Background: Combined immunotherapy has shown promising results in the treatment of advanced HCC, whereas the priority population that would respond to the combined immunotherapy is still elusive. In addition, HCC with asymptomatic hyperamylasemia was not reported previously.
Case Presentation: An aged patient was diagnosed as HCC with BCLC stage C (bone metastasis).