Publications by authors named "Rudy Dupree"
Article Synopsis
- There are significant uncertainties about whether PD-1 and PD-L1 inhibitors can be used interchangeably, impacting clinical decisions and healthcare budgets.
- The paper reviews the complicated regulatory environment and market competition surrounding these inhibitors, revealing issues with clinical trial designs that make it hard to assess their interchangeability.
- To improve understanding of their interchangeability, the authors suggest more rigorous research methods, including specific types of trials and a new evaluation framework.
A blueprint for health technology assessment capacity building: lessons learned from Malta.
Int J Technol Assess Health Care
February 2024
Objectives: The development and strengthening of health technology assessment (HTA) capacity on the individual and organizational level and the wider environment is relevant for cooperation on HTAs. Based on the Maltese case, we provide a blueprint for building HTA capacity.
Methods: A set of activities were developed based on Pichler et al.
The 5-HT-receptor agonist eltoprazine has a behavioral drug signature that resembles that of a variety of psychostimulant drugs, despite the differences in receptor binding profile. These psychostimulants are effective in treating impulsivity disorders, most likely because they increase norepinephrine (NE) and dopamine (DA) levels in the prefrontal cortex. Both amphetamine and methylphenidate, however, also increase dopamine levels in the nucleus accumbens (NAc), which has a significant role in motivation, pleasure, and reward.
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