Clinical and epidemiological profile of oral squamous cell carcinoma in young adults: a multicentric study in Argentina.

Introduction: Oral squamous cell carcinoma (OSCC) is an increasingly prevalent disease, especially among young patients. Research on the factors influencing the progression of this disease is still limited in Latin America.

Objective: To analyze the sociodemographic, clinical-pathological characteristics as well as risk factors involved in young adults with OSCC.

Clinical and aetiological factors in spongiotic gingival hyperplasia.

Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a rare gingival lesion characterized by exuberant epithelial proliferation. Its etiology remains unclear, with few studies exploring its clinical and histopathological features. This retrospective study aimed to analyze the demographic, clinical, and etiological characteristics of LJSGH across 13 diagnostic centers in Latin America.

Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival.

Oral squamous cell carcinoma (OSCC) is one of the most frequent types of oral cancer in developing countries and its burden correlates with exposure to tobacco and excessive alcohol consumption. Toll like receptors (TLRs) are major sensors of inflammatory stimuli, from both microbial and sterile causes and as such, they have been related to tumor progression and metastasis. Here, we evaluated the expression of TLR2, 4 and 9 as well as CD3+, CD8+ and Granzyme B+ cell infiltration by immunohistochemistry in oral samples of 30 patients with OSCC, classified according to their consumption of alcohol.

Reexamination of delays in diagnosis of oral cancer following an intervention program in Cordoba, Argentina.

Objective: We compare the results of delay in oral cancer diagnosis before and after a campaign directed toward dentists and raising awareness of the population to achieve early diagnosis of oral cancer in Córdoba, Argentina. The campaign included training dentists in diagnostic skills and a public awareness program through media and networks.

Study Design: Clinical records (period 1: before intervention program, n = 70; period 2: after intervention program, n = 60) of patients presenting with oral squamous cell carcinoma treated in 2 referral centers were analyzed.

Effect of two mouthwashes on salivary ph.

To analyze the effect of two mouthwashes on salivary pH and correlate it with age, buffer capacity and saliva flow rate in healthy volunteers, a crossover phase IV clinical study involving three age-based groups was designed. Two commercial mouthwashes (MW), Cool Mint ListerineR (MWa) and Periobacter R (MWb) were used. The unstimulated saliva of each individual was first characterized by measuring flow rate, pH, and buffer capacity.

Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.

Unlabelled: The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC.

Oral cancer mortality in the province of Cordoba, Argentine Republic in the period 1975-2000. A comparative study with other populations.

Unlabelled: Malignant neoplasm (MN) mortality worldwide ranks among the first four causes of death, in the 1990 decade (1-4). The aim of this work is to study the eight most frequent MN mortality rates, and especially that one caused by oral cancer (OC) in the province of Cordoba, Argentine Republic, in the period between 1975 and 2000, in order to analyze its characteristics and compare with other populations in America and Europe.

Material And Methods: The data were provided by the provincial and national Health Ministry and Globocan 2000.

Antifungal topical therapy in oral chronic candidosis. A comparative study.

The aim of the present paper was to evaluate the effect of fenticonazole and to compare it with that of ketoconazole and nystatin in the topical treatment of oral chronic candidosis. Eighty patients diagnosed with erythematous chronic candidosis were divided into four groups, according to the cream they were provided with 3% fenticonazole, 2% fenticonazole, 100000UI nystatin, and 2% ketoconazole in orabase respectively. A clinical assessment was made at 7, 15, 30 and 45 days.