Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens.

Clinical trials are considered to be the largest contributor to pharmaceutical development costs. However, public disclosure of the costs of individual clinical trials is rare. Médecins Sans Frontières (MSF) sponsored a phase 2b-3 randomised controlled trial (TB-PRACTECAL), which identified a new treatment regimen for drug-resistant TB.

"I Owe Her So Much; Without Her I Would Be Dead": Developing a Model of Mother-Infant Bonding Following a Maternal Antenatal HIV Diagnosis.

Women can face a period of psychological vulnerability following antenatal HIV diagnosis, affecting feelings about both the pregnancy and motherhood. Our study explored the impact of being diagnosed with HIV during pregnancy on mother-infant bonding. Grounded Theory was used to assess perceived challenges and facilitating factors for mother-infant bonding for 10 mothers given an HIV diagnosis during pregnancy.