Publications by authors named "Rongyu Lan"
A novel strategy for spinal cord reconstruction via vascularized allogeneic spinal cord transplantation combine spinal cord fusion.
CNS Neurosci Ther
September 2024
Aims: Spinal cord injuries (SCI) pose persistent challenges in clinical practice due to the secondary injury. Drawing from our experience in spinal cord fusion (SCF), we propose vascularized allogeneic spinal cord transplantation (vASCT) as a novel approach for SCI, much like organ transplantation has revolutionized organ failure treatment and vascularized composite-tissue allotransplantation has addressed limb defects.
Materials And Methods: In this study, 24 dogs were paired and underwent vASCT, with donor spinal cord grafts and polyethylene glycol (PEG) application for SCF.
Background: Spinal cord injury (SCI) is a severe impairment of the central nervous system, leading to motor, sensory, and autonomic dysfunction. The present study investigates the efficacy of the polyethylene glycol (PEG)-mediated spinal cord fusion (SCF) techniques, demonstrating efficacious in various animal models with complete spinal cord transection at the T10 level. This research focuses on a comparative analysis of three SCF treatment models in beagles: spinal cord transection (SCT), vascular pedicle hemisected spinal cord transplantation (vSCT), and vascularized allograft spinal cord transplantation (vASCT) surgical model.
View Article and Find Full Text PDF[Effect of High-Concentration Uric Acid on Nitric Oxide].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2023
Article Synopsis
- Uric acid is the final product of purine metabolism, and high levels in the body (hyperuricemia) can lead to various health issues due to oxidative stress and inflammation.
- The presence of high uric acid affects the availability of nitric oxide in the body, which plays a crucial role in many physiological functions.
- This review highlights the mechanisms by which high uric acid reduces nitric oxide levels and aims to improve understanding of the links between hyperuricemia and other metabolic diseases.
[Microsurgical thinned anterolateral thigh perforator flap to repair soft tissue defects of foot and ankle].
Zhongguo Gu Shang
August 2023
Objective: To explore method and clinical effect of microsurgical thinned anterolateral thigh perforator flap to repair soft tissue defects of foot and ankle.
Methods: From March 2017 to January 2022, totally 20 patients with soft tissue defects of ankle joint were treated with micro-thinning anterolateral perforator flap for free transplantation, included 13 males and 7 females, aged from 22 to 58 years old with an average of (36.45±12.
Aims: Our team tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal (mice, rats, and beagles) models with complete spinal cord transection. To further explore the application of SCF for the treatment of paraplegic patients, we developed a new clinical procedure for SCF called vascular pedicle hemisected spinal cord transplantation (vSCT) and tested this procedure in eight paraplegic participants.
Methods: Eight paraplegic participants (American Spinal Injury Association, ASIA: A) were enrolled and treated with vSCT (PEG was applied to the sites of spinal cord transplantation).
Article Synopsis
- The study presents a new surgical method called sural nerve transplantation (SNT) designed to improve conditions for paraplegic patients suffering from spinal cord injuries (SCI) between T1 and T12.
- In a clinical trial involving 12 patients, results showed improvements in autonomic nerve functions and relief from central pain in several participants, along with some recovery of sensory and motor functions.
- While SNT did not fully restore spinal cord continuity, it successfully established some nerve connections and improved certain functions in most patients, suggesting its potential as a treatment option for SCI.