Publications by authors named "Rongdong He"
Background: cyst fluid (EgCF) is a complex mixture of parasite's containing a variety of antigens. Th9 cells are a newly reported subpopulation of Th cells whose primary function is to secrete IL-9 and exert biological effects. Research on whether antigens in the vesicle fluid can evade the host immune response by increasing IL-9 secretion is limited.
View Article and Find Full Text PDFThe protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury.
Cytokine
February 2025
Article Synopsis
- The study investigates the role of the vagus nerve's α7nAChR receptor in regulating interleukin-22, which may help mitigate acute liver injury.
- Carbon tetrachloride was used to induce liver injury in rat models and human liver cells, revealing that interfering with α7nAChR leads to higher liver damage markers like AST and ALT.
- The findings suggest that enhancing vagus nerve activity and interleukin-22 levels can aid liver recovery, while blocking these pathways may worsen liver injury.
Article Synopsis
- Cystic Echinococcosis (CE) is a disease caused by the parasite Echinococcus granulosus, leading to liver damage, and there is a concern that certain immune responses can worsen this condition.
- This study investigated how the hormone Ghrelin affects the progression of liver lesions in mice infected with E.g, examining serum levels, local expression around lesions, and cellular responses to Ghrelin.
- Results showed increased Ghrelin levels in E.g-infected mice at earlier stages, significant interaction with immune cells, and Ghrelin's ability to suppress inflammatory and fibrotic responses while blocking its receptor hindered the growth of infected cells in lab tests.
Cystic echinococcosis (CE) is a zoonotic disease caused by the parasite (), which can lead to the formation of liver lesions. Research indicates that releases both Toll-like receptor 2 (TLR2) and Interleukin-9 (IL-9), which can potentially impair the body's innate immune defenses and compromise the liver's ability to fight against diseases. To investigate the role of TLR2 and IL-9 in liver damage caused by infection, samples were initially collected from individuals diagnosed with CE.
View Article and Find Full Text PDFBackground: For decades, studies have demonstrated the anti-inflammatory potential of proteins secreted by helminths in allergies and asthma. Previous studies have demonstrated the immunomodulatory capabilities of Succinate Coenzyme A ligase beta-like protein (SUCLA-β) derived from Trichinella spiralis, a crucial excretory product of this parasite.
Objective: To explore the therapeutic potential of SUCLA-β in alleviating and controlling ovalbumin (OVA)-induced allergic asthma, as well as its influence on host immune modulation.
Effects of small molecule inhibitor SW033291 on hepatic ischemia-reperfusion injury in mice.
Biochem Biophys Res Commun
July 2022
Hepatic ischemia-reperfusion injury (IRI) is an important factor in the recovery of liver function and prognosis after liver surgery. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) small molecule inhibitor SW033291 is thought to play an important role in promoting tissue regeneration. The aim of this study was to investigate the effect of 15-PGDH on ischemia-reperfusion injury in mouse liver.
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