Design of a Neonatal Orthotopic Metastatic Xenograft Model of Hepatoblastoma in Mice.

Introduction: Hepatoblastoma (HB) is the most frequent liver cancer in children, typically occurring before the age of five. Thanks to the combination of chemotherapy and surgery, the 5-year survival rate following diagnosis is approximately 83%. Today, the main challenge is the efficient treatment of high-risk patients, particularly those presenting with lung metastasis or experiencing relapse.

An Adaptive, Situation-Based Risk Assessment and Security Enforcement Framework for the Maritime Sector.

Maritime processes involve actors and systems that continuously change their underlying environment, location and threat exposure. Thus, risk mitigation requires a dynamic risk assessment process, coupled with an adaptive, event driven security enforcement mechanism, to efficiently deal with dynamically evolving risks in a cost efficient manner. In this paper, we propose an adaptive security framework that covers both situational risk assessment and situational driven security policy deployment.