Hindering Memory Suppression by Perturbing the Right Dorsolateral pFC.

A reminder of the past can trigger the involuntary retrieval of an unwanted memory. Yet, we can intentionally stop this process and thus prevent the memory from entering awareness. Such suppression not only transiently hinders the retrieval of the memory, it can also induce forgetting.

Concurrent representations of reinstated and transformed memories and their modulation by reward.

An integral part of episodic retrieval is the reinstatement of neural activity that was present in the medial temporal lobe during encoding. However, neural memory representations do not remain static. Consolidation promotes the transformation of representations that are specific to individual episodes toward more generalized representations that reflect commonalities across episodes.

Emotional past and future events after pulvinar damage: A neuropsychological case series.

The pulvinar nucleus represents a key neural structure involved in signalling emotional content in the domain of visual perception, whereas its role in the processing of simulated emotional events is less clear. fMRI research has hinted at a role for the pulvinar in imagined emotional scenarios, but the evidence is mixed and this proposal has yet to be tested using the lesion study method. In this study, 3 patients with unilateral lesions to the pulvinar, and 10 matched control participants, completed a set of well-established tasks that required them to think about emotional past and future events.

A reward effect on memory retention, consolidation, and generalization?

Reward improves memory through both encoding and consolidation processes. In this preregistered study, we tested whether reward effects on memory generalize from high-rewarded items to low-rewarded but episodically related items. Fifty-nine human volunteers incidentally encoded associations between unique objects and repeated scenes.

The first balloon-borne sample analysis of atmospheric carbonaceous components reveals new insights into formation processes.

Atmospheric aerosol optical, physical, and chemical properties play a fundamental role in the Earth's climate system. A better understanding of the processes involved in their formation, evolution, and interaction with radiation and the water cycle is critical. We report the analysis of atmospheric molecules/particles collected with a new sampling system that flew under regular weather balloons for the first time.

Characterization of the Autoxidation of Terpenes at Elevated Temperature Using High-Resolution Mass Spectrometry: Formation of Ketohydroperoxides and Highly Oxidized Products from Limonene.

Low-temperature experiments on the oxidation of limonene-O-N mixtures were conducted in a jet-stirred reactor (JSR) over a range of temperatures (520-800 K) under fuel-lean conditions (equivalence ratio φ = 0.5) with a short residence time (1.5 s) and a pressure of 1 bar.

Simulation-based learning influences real-life attitudes.

Humans can vividly simulate hypothetical experiences. This ability draws on our memories (e.g.

Suppression weakens unwanted memories via a sustained reduction of neural reactivation.

Aversive events sometimes turn into intrusive memories. However, prior evidence indicates that such memories can be controlled via a mechanism of retrieval suppression. Here, we test the hypothesis that suppression exerts a sustained influence on memories by deteriorating their neural representations.

Towards a Comprehensive Characterization of the Low-Temperature Autoxidation of Di-n-Butyl Ether.

In the present study, we investigated the oxidation of 2500 ppm of di-n-butyl ether under fuel-rich conditions (φ = 2) at low temperatures (460-780 K), a residence time of 1 s, and 10 atm. The experiments were carried out in a fused silica jet-stirred reactor. Oxidation products were identified and quantified in gas samples by gas chromatography and Fourier transform infrared spectrometry.

Promoting farsighted decisions via episodic future thinking: A meta-analysis.

Episodic future thinking (EFT) denotes our capacity to imagine prospective events. It has been suggested to promote farsighted decisions that entail a trade-off between short-term versus long-term gains. Here, we meta-analyze the evidence for the impact of EFT on such intertemporal choices that have monetary or health-relevant consequences.

Memory suppression and its deficiency in psychological disorders: A focused meta-analysis.

It is still debated whether suppressing the retrieval of unwanted memories causes forgetting and whether this constitutes a beneficial mechanism. To shed light on these 2 questions, we scrutinize the evidence for such suppression-induced forgetting (SIF) and examine whether it is deficient in psychological disorders characterized by intrusive thoughts. Specifically, we performed a focused meta-analysis of studies that have used the procedure to test SIF in individuals either affected by psychological disorders or exhibiting high scores on related traits.

Variability in the analysis of a single neuroimaging dataset by many teams.

Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses. The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data.

Forming attitudes via neural activity supporting affective episodic simulations.

Humans have the adaptive capacity for imagining hypothetical episodes. Such episodic simulation is based on a neural network that includes the ventromedial prefrontal cortex (vmPFC). This network draws on existing knowledge (e.

An adaptive function of mental time travel: Motivating farsighted decisions.

The episodic memory system allows us to experience the emotions of past, counterfactual, and prospective events. We outline how this phenomenological experience can convey motivational incentives for farsighted decisions. In this way, we challenge important arguments for Mahr & Csibra's (M&C's) conclusion that future-oriented mental time travel is unlikely to be a central function of episodic memory.

Phosphonate-Mediated Immobilization of Rhodium/Bipyridine Hydrogenation Catalysts.

RhL complexes of phosphonate-derivatized 2,2'-bipyridine (bpy) ligands L were immobilized on titanium oxide particles generated in situ. Depending on the structure of the bipy ligand-number of tethers (1 or 2) to which the phosphonate end groups are attached and their location on the 2,2'-bipyridine backbone (4,4'-, 5,5'-, or 6,6'-positions)-the resulting supported catalysts showed comparable chemoselectivity but different kinetics for the hydrogenation of 6-methyl-5-hepten-2-one under hydrogen pressure. Characterization of the six supported catalysts suggested that the intrinsic geometry of each of the phosphonate-derivatized 2,2'-bipyridines leads to supported catalysts with different microstructures and different arrangements of the RhL species at the surface of the solid, which thereby affect their reactivity.

Episodic Future Thinking: Mechanisms and Functions.

Episodic future thinking refers to the capacity to imagine or simulate experiences that might occur in one's personal future. Cognitive, neuropsychological, and neuroimaging research concerning episodic future thinking has accelerated during recent years. This article discusses research that has delineated cognitive and neural that support episodic future thinking as well as the that episodic future thinking serves.

Increased hippocampus to ventromedial prefrontal connectivity during the construction of episodic future events.

Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. However, the precise role played by each of these structures and, indeed, the direction of information flow between them during episodic simulation, is still not well understood.

Characterizing the role of the hippocampus during episodic simulation and encoding.

The hippocampus has been consistently associated with episodic simulation (i.e., the mental construction of a possible future episode).

Imagining the future: The core episodic simulation network dissociates as a function of timecourse and the amount of simulated information.

Neuroimaging data indicate that episodic memory (i.e., remembering specific past experiences) and episodic simulation (i.

Priming, not inhibition, of related concepts during future imagining.

Remembering the past and imagining the future both involve the retrieval of details stored in episodic memory and rely on the same core network of brain regions. Given these parallels, one might expect similar component processes to be involved in remembering and imagining. While a strong case can be made for the role of inhibition in memory retrieval, few studies have examined whether inhibition is also necessary for future imagining and results to-date have been mixed.

Reducing future fears by suppressing the brain mechanisms underlying episodic simulation.

Imagining future events conveys adaptive benefits, yet recurrent simulations of feared situations may help to maintain anxiety. In two studies, we tested the hypothesis that people can attenuate future fears by suppressing anticipatory simulations of dreaded events. Participants repeatedly imagined upsetting episodes that they feared might happen to them and suppressed imaginings of other such events.

Comparison of Zirconium Phosphonate-Modified Surfaces for Immobilizing Phosphopeptides and Phosphate-Tagged Proteins.

Different routes for preparing zirconium phosphonate-modified surfaces for immobilizing biomolecular probes are compared. Two chemical-modification approaches were explored to form self-assembled monolayers on commercially available primary amine-functionalized slides, and the resulting surfaces were compared to well-characterized zirconium phosphonate monolayer-modified supports prepared using Langmuir-Blodgett methods. When using POCl3 as the amine phosphorylating agent followed by treatment with zirconyl chloride, the result was not a zirconium-phosphonate monolayer, as commonly assumed in the literature, but rather the process gives adsorbed zirconium oxide/hydroxide species and to a lower extent adsorbed zirconium phosphate and/or phosphonate.

Repetition-Related Reductions in Neural Activity during Emotional Simulations of Future Events.

Simulations of future experiences are often emotionally arousing, and the tendency to repeatedly simulate negative future outcomes has been identified as a predictor of the onset of symptoms of anxiety. Nonetheless, next to nothing is known about how the healthy human brain processes repeated simulations of emotional future events. In this study, we present a paradigm that can be used to study repeated simulations of the emotional future in a manner that overcomes phenomenological confounds between positive and negative events.

Specifying the core network supporting episodic simulation and episodic memory by activation likelihood estimation.

It has been suggested that the simulation of hypothetical episodes and the recollection of past episodes are supported by fundamentally the same set of brain regions. The present article specifies this core network via Activation Likelihood Estimation (ALE). Specifically, a first meta-analysis revealed joint engagement of expected core-network regions during episodic memory and episodic simulation.