Publications by authors named "Rohit Jhawar"
Background: Arrhythmic risk stratification in mitral valve prolapse (MVP) without significant mitral regurgitation (MR) remains elusive. Unsupervised machine learning may reveal phenotypic variation among arrhythmic MVP without severe MR.
Objectives: In this study, the authors hypothesized that hierarchical clustering of echocardiographic and 12-lead electrocardiographic (ECG) parameters alone could identify MVP phenotypes without severe MR associated with sustained ventricular arrhythmia and excess mortality.
Unlabelled: All eukaryotic cells secrete exosomes, a type of extracellular vesicles (EVs) derived from the endocytic compartments known as multivesicular bodies (MVBs), or late endosomes (LEs). Exosomes contain a diverse range of cargo such as nucleic acids, proteins, lipids and small molecules but whether these contents have a biological function remains an area of intense investigation. Over the last decade, numerous studies have described the transcriptome of exosomes but very little is known about the RNA content of the MVBs, the source compartment for exosome biogenesis.
View Article and Find Full Text PDFInheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study.
Circ Cardiovasc Imaging
January 2025
Background: A subset of patients with mitral valve prolapse (MVP), a highly heritable condition, experience sudden cardiac arrest (SCA) or sudden cardiac death (SCD). However, the inheritance of phenotypic imaging features of arrhythmic MVP remains unknown.
Methods: We recruited 23 MVP probands, including 9 with SCA/SCD and 14 with frequent/complex ventricular ectopy.
Interstitial fibrosis and arrhythmic mitral valve prolapse: Unraveling sex-based differences.
J Cardiovasc Magn Reson
December 2024
Article Synopsis
- The study investigates the relationship between interstitial fibrosis and arrhythmic mitral valve prolapse (AMVP) without including cases with severe mitral regurgitation (MR) or mitral annular disjunction (MAD), especially noting the role of female sex in this condition.
- Researchers used cardiac magnetic resonance (CMR) to measure extracellular volume fraction (ECV%) as a marker for interstitial fibrosis in 65 MVP cases and found that 38% were classified as AMVP.
- Results showed that AMVP patients had significantly higher global ECV% compared to non-AMVP patients, with this association being particularly strong in females, indicating a possible sex-related risk factor for arrhythmias in those with MVP.
Primary Atriopathy in Mitral Valve Prolapse: Echocardiographic Evidence and Clinical Implications.
Circ Cardiovasc Imaging
June 2024
Background: Prominent multi-scallop systolic leaflet displacement toward the left atrium (atrialization) is typically observed in bileaflet mitral valve prolapse (MVP) with mitral annular disjunction. We hypothesized that mitral leaflet atrialization is associated with an underlying left atrial (LA) myopathy characterized by progressive structural and functional abnormalities, irrespective of mitral regurgitation (MR) severity.
Methods: We identified 334 consecutive patients with MVP, no prior atrial fibrillation, and comprehensive clinical and echocardiographic data.