Publications by authors named "Rohan Alibutud"
Article Synopsis
- Autism spectrum disorder (ASD) is characterized by similar behaviors, suggesting shared causes, but also shows a wide variety of clinical profiles that hint at personalized conditions.
- Research using induced pluripotent stem cells (iPSCs) from patients with two different ASD subtypes revealed common issues in neural precursor cell (NPC) growth and movement, despite no genetic similarities.
- An unbiased screening identified shared signaling pathways, particularly the mTOR pathway, as a critical factor in these defects, indicating that different genetic backgrounds in ASD can lead to common developmental issues due to mTOR dysregulation.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restrictive interests and/or repetitive behaviors and deficits in social interaction and communication. ASD is a multifactorial disease with a complex polygenic genetic architecture. Its genetic contributing factors are not yet fully understood, especially large structural variations (SVs).
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