Smoking is Associated With Poorer Survival Outcomes Following Nephroureterectomy for Upper Tract Urothelial Cancer.

Objective: To examine the oncologic outcomes in patients treated for UTUC by radical nephroureterectomy (RNU) relative to their smoking history in a contemporary cohort that includes use of neoadjuvant and intravesical chemotherapy (IVC).

Methods: We analyzed a multi-institutional cohort of patients treated with RNU for UTUC between 2000 and 2020. Patients were classified as never smokers, those with a <20 pack-year smoking history, and those with a ≥20 pack-years of smoking history.

Oncologic and survival outcomes in patients undergoing radical nephroureterectomy with preoperative or iatrogenic dialysis dependence.

Purpose: Radical nephroureterectomy (RNU) is the gold standard treatment for high-risk upper tract urothelial carcinoma (UTUC). However, the oncologic control afforded by RNU may be accompanied by significant renal function decline. Data regarding patients with immediate end-stage renal disease (ESRD) after RNU is limited.

Predictors and Patterns of Nonurothelial Recurrence After Nephroureterectomy for Upper Tract Urothelial Carcinoma (UCAN Collaboration).

Purpose: After radical nephroureterectomy for upper tract urothelial carcinoma, 25% of patients experience distant metastasis within 5 years. Nonurothelial recurrence is associated with poor prognosis and survival, with ∼80% of patients dying within 2 years. We evaluated predictors, patterns, and timing of recurrences after radical nephroureterectomy, and the association between recurrence location and cancer-specific survival.

Real-World Management of High-Risk Prostate Cancer Post-Radical Prostatectomy: Insights from a Regional Quality Collaborative.

Prostate cancer (CaP) remains the most diagnosed malignancy in men, and the incidence of high-grade disease at diagnosis is increasing [...