Publications by authors named "Robin D V Kleinert"
Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II.
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- TMPRSS2 is an accessory protease that increases the entry of SARS-CoV-2 into cells expressing ACE2, impacting how the virus interacts with host cells during infection.
- Experiments showed that TMPRSS2 enhances the internalization of the virus, improves early replication rates, and modifies immune responses, depending on the virus variant.
- The study reveals that TMPRSS2 not only affects viral uptake and replication but also leads to increased cell death and drives the evolution of viral mutations, linking these processes to the effectiveness of the host's immune response.
Yellow fever virus (YFV) represents a re-emerging zoonotic pathogen, transmitted by mosquito vectors to humans from primate reservoirs. Sporadic outbreaks of YFV occur in endemic tropical regions, causing a viral hemorrhagic fever (VHF) associated with high mortality rates. Despite a highly effective vaccine, no antiviral treatments currently exist.
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