Publications by authors named "Robin A Prentice"
Article Synopsis
- TgDCX is a protein linked to the conoid fibers in Toxoplasma that is crucial for maintaining the conoid structure and enabling parasite invasion; its deletion leads to structural instability.
- Research shows that isolated conoid fibers with TgDCX maintain their curvature, but without it, the fibers become unstable, and TgDCX uniquely promotes the formation of curved microtubule arcs.
- The study highlights how different orthologues of TgDCX vary in their ability to interact with microtubules and suggests that specific features of TgDCX are key for its role in enabling Toxoplasma to invade host cells effectively.
Iron is essential for the pathogenicity and virulence of Mycobacterium tuberculosis, which synthesises salicyl-capped siderophores (mycobactins) to acquire this element from the host. MbtA is the adenylating enzyme that catalyses the initial reaction of mycobactin biosynthesis and is solely expressed by mycobacteria. A 3200-member library comprised of lead-like, structurally diverse compounds was screened against M.
View Article and Find Full Text PDF