Expanding the Antiviral Spectrum of Scorpion-Derived Peptides Against Toscana Virus and Schmallenberg Virus.

Toscana virus (TOSV) and Schmallenberg virus (SBV) are arthropod-borne viruses from the class, posing significant human and animal health threats. TOSV, endemic to the Mediterranean region, is a notable human pathogen detected in various animals, suggesting potential zoonotic reservoirs. SBV emerged in Europe in 2011, affecting ruminants and causing reproductive issues, with substantial economic implications.

The inhibitory potential of three scorpion venom peptides against multidrug-resistant .

Background: The rise of drug-resistant bacterial infections, particularly those caused by underscores the urgent need for novel therapeutic candidates. Hospital-acquired infections from carbapenemase (KPC)-producing bacteria pose a serious health threat, particularly impacting the respiratory and urinary tracts. This study investigates the antibacterial efficacy of three antimicrobial peptides, called pantinins, derived from scorpions' venom against and various KPC-producing clinical isolates.

Antiviral Properties of Leaf Extracts against Respiratory Viruses.

() is a plant widely used for its beneficial properties both in medical and non-medical fields. Because they produce bioactive metabolites, plants are a major resource for drug discovery. In this study, two different cultivars of leaves of (Salento and Barletta) were obtained by maceration or microwave-assisted extraction (MAE).

Evaluation of antifungal spectrum of Cupferron against Candida albicans.

Candida albicans is an opportunistic yeast accounting for about 50-90 % of all cases of candidiasis in humans, ranging from superficial to systemic potentially life-threatening infections. The presence of several virulence factors, including biofilm, hyphal transition, and proteolytic enzymes production, worsens the fungal infections burden on healthcare system resources. Hence, developing new bioactive compounds with antifungal activity is a pressing urgence for the scientific community.

A neutralizing antibody prevents postfusion transition of measles virus fusion protein.

Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the general population declines and as populations of immunocompromised individuals, who cannot be vaccinated, increase. There are no approved therapeutics for MeV. Neutralizing antibodies targeting viral fusion are one potential therapeutic approach but have not yet been structurally characterized or advanced to clinical use.

Cupferron impairs the growth and virulence of Escherichia coli clinical isolates.

Aims: Multidrug resistance is a worrying problem worldwide. The lack of readily available drugs to counter nosocomial infections requires the need for new interventional strategies. Drug repurposing represents a valid alternative to using commercial molecules as antimicrobial agents in a short time and with low costs.

Antiviral Activity of Leaf Extracts against HSV-1, HCoV-229E and PV-1.

plant extract showed antimicrobial activity, but no evidence concerning its antiviral properties was reported. The antiviral activity of the methanolic extract (MeOH) and its -hexane (H) and ethyl acetate (EA) fractions against virus-1 (HSV-1), Human coronavirus (HCoV) -229E, and Poliovirus-1 (PV-1) was investigated in the different phases of viral infection in the VERO CCL-81 cell line. To confirm the antiviral efficacy, a qPCR was conducted.

In Vitro Antibacterial and Anti-Inflammatory Activity of Leaf Extract against .

() is the main causative agent of acne vulgaris. The study aims to evaluate the antimicrobial activity of a natural product, leaf extract, against . Preliminary chemical-physical characterization of the extract was carried out by means of FT-IR, TGA and XPS analyses.