GABA, Glx, and GSH in the cerebellum: their role in motor performance and learning across age groups.

Introduction: The cerebellum is essential for motor control and learning, relying on structural and functional integrity. Age-related atrophy leads to Purkinje cell loss, but subtle neurochemical changes in GABA, Glx (glutamate + glutamine), and glutathione (GSH) may precede degeneration and contribute to motor decline.

Methods: 25 younger (YA) and 25 older adults (OA) were included in this study.