Publications by authors named "Riku Yoshii"
Eur J Med Chem
November 2022
Article Synopsis
- Fluorizoline is a cytotoxic compound that targets specific proteins (PHB1/2) to inhibit cancer growth by affecting key pathways, including enhancing the inhibitor p21 to kill cancer cells.
- The study identifies new fluoroziline analogues with improved effectiveness against cancer cells, specifically noting that some have better anti-C-RAF and anti-MEK activities than fluorizoline itself.
- Additionally, a different analogue was found that exhibits effects opposite to fluorizoline, which could help researchers study how PHB signaling functions in cancer and other diseases.
